| Gene Information | |
|---|---|
| Gene Name | KLHL20 |
| Organism | Homo sapiens (Human) |
| Gene Length | 609 |
| Protein Names | Kelch-like protein 20 (Kelch-like ECT2-interacting protein) (Kelch-like protein X) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000076321 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9Y2M5 |
| Gene Card | KLHL20 |
| Uniprot ID | Q9Y2M5 |
| Pfam | PF07707; PF00651; PF01344 |
| In ASD | no |
| Allosteric Prediction | no (-0.32138424) |
| Ortholog in Animals | Alpaca_ KLHL20 ( ortholog_one2one ) Dog_ KLHL20 ( ortholog_one2one ) GuineaPig_ KLHL20 ( ortholog_one2one ) Macaque_ KLHL20 ( ortholog_one2one ) Mouse_ Klhl20 ( ortholog_one2one ) Pig_ KLHL20 ( ortholog_one2one ) Rat_ Klhl20 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | KLHL40, KLHDC7B, GAN, BACH1, KLHL10, KLHL42, KLHL21, KLHL32, KBTBD7, KBTBD6, BACH2, KLHL30, KLHL15, KLHL38, KLHL41, KLHL26, KLHL17, KBTBD3, KLHL13, KLHL9, KLHL18, KLHL23, KLHDC7A, KLHL31, IVNS1ABP, KLHL1, KEAP1, KLHL8, KLHL2, KLHL29, KBTBD12, KLHL34, KLHL7, KLHL33, KLHL36, KLHL28, KBTBD11, KLHL14, CCIN, BTBD18, IPP, KLHDC8B, KLHL6, KLHL24, KLHL5, KBTBD13, KBTBD8, KLHL3, KLHL35, KLHL22, KBTBD2, KLHL12, KLHL4, KLHDC8A |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5YQ4 (X-ray 1.58A ) 6GY5 (X-ray 1.09A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, perinuclear region. Nucleus. Golgi apparatus, trans-Golgi network. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Note=Localizes in the perinuclear region in normal conditions. Following IFN-alpha or IFN-gamma treatment, it is relocalized and sequestrated to the PML nuclear bodies, preventing DAPK1 ubiquitination (PubMed:20389280). {ECO:0000269|PubMed:20389280}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |