| Gene Information | |
|---|---|
| Gene Name | NPHP15 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1460 |
| Protein Names | Centrosomal protein of 164 kDa (Cep164) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9UPV0 |
| Gene Card | CEP164 |
| Uniprot ID | Q9UPV0 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in several cell lines. {ECO:0000269|PubMed:17954613}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7NWJ (NMR - ) 7O06 (X-ray 1.60A ) 7O0S (X-ray 1.70A ) 7O3B (X-ray 2.40A ) |
| DBSNP | rs387907309 rs387907310 rs490262 rs2305830 rs573455 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:26337392}. Nucleus. Note=Localizes specifically to very distally located appendage structures on the mature centriole from which initiate PC formation (PubMed:26337392). Persisted at centrioles throughout mitosis. Expressed in chromatin-enriched nuclear fraction of HeLa cells. In response to DNA damage, it translocates to nuclear foci that contain the DNA damage response proteins KAT5/TIP60 and CHEK1. {ECO:0000269|PubMed:26337392}. |
| Mouse PG classification | NA |
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