| Gene Information | |
|---|---|
| Gene Name | NPEPPS |
| Organism | Homo sapiens (Human) |
| Gene Length | 919 |
| Protein Names | Puromycin-sensitive aminopeptidase (PSA) (EC 3.4.11.14) (Cytosol alanyl aminopeptidase) (AAP-S) |
| Target Name | puromycin-sensitive aminopeptidase |
| Target Type | Clinical trial target |
| Gene Age | 1714 ( ENSG00000141279 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P55786 |
| Gene Card | NPEPPS |
| Uniprot ID | P55786 |
| Pfam | PF11838; PF01433; PF17900 |
| In ASD | no |
| Allosteric Prediction | yes (1.109334301) |
| Ortholog in Animals | Alpaca_ NPEPPS ( ortholog_one2one ) Alpaca_ NPEPPS ( ortholog_one2many ) Dog_ NPEPPS ( ortholog_one2one ) GuineaPig_ NPEPPS ( ortholog_one2one ) Macaque_ NPEPPS ( ortholog_one2one ) Mouse_ Npepps ( ortholog_one2one ) Pig_ NPEPPS ( ortholog_one2one ) Rat_ Npepps ( ortholog_one2one ) Rabbit_ NPEPPS ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RNPEPL1, ERAP1, ENPEP, AOPEP, LTA4H, TRHDE, LNPEP, LVRN, ANPEP, RNPEP, ERAP2 |
| Tissue | NA |
| Tissue Specificity | Detected in liver, epithelium of renal tubules, epithelium of small and large intestine, gastric epithelial cells, and alveoli of the lung (at protein level). {ECO:0000269|PubMed:10978616}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:10978616}. Nucleus {ECO:0000305}. |
| Mouse PG classification | NA |
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