| Gene Information | |
|---|---|
| Gene Name | KATNAL1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 490 |
| Protein Names | Katanin p60 ATPase-containing subunit A-like 1 (Katanin p60 subunit A-like 1) (EC 5.6.1.1) (p60 katanin-like 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000102781 ) |
| Evolutionary Stage | Euk_Archaea |
| AlphaFoldDB | Q9BW62 |
| Gene Card | KATNAL1 |
| Uniprot ID | Q9BW62 |
| Pfam | PF00004; PF17862; PF09336 |
| In ASD | no |
| Allosteric Prediction | no (-1.058644381) |
| Ortholog in Animals | Alpaca_ KATNAL1 ( ortholog_one2one ) Alpaca_ KATNAL1 ( ortholog_one2many ) Dog_ KATNAL1 ( ortholog_one2one ) GuineaPig_ KATNAL1 ( ortholog_one2one ) Macaque_ KATNAL1 ( ortholog_one2one ) Mouse_ Katnal1 ( ortholog_one2one ) Pig_ KATNAL1 ( ortholog_one2one ) Rat_ Katnal1 ( ortholog_one2one ) Rabbit_ KATNAL1 ( ortholog_one2one ) |
| Ohnologs | KATNA1 |
| Paralogs | FIGNL2, VPS4A, FIGN, ATAD1, FIGNL1, KATNAL2, SPAST, VPS4B, KATNA1 |
| Tissue | NA |
| Tissue Specificity | Expressed in testis, restricted to Sertoli cells (at protein level). {ECO:0000269|PubMed:22654668}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);0.057143(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6B5C (X-ray 2.40A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000255|HAMAP-Rule:MF_03024, ECO:0000269|PubMed:22654668}. Cytoplasm {ECO:0000269|PubMed:26929214}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:26929214}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:26929214}. Note=Colocalizes with microtubules throughout the basal and adluminal compartments of Sertoli cells (By similarity). Localizes within the cytoplasm, partially overlapping with microtubules, in interphase and to the mitotic spindle and spindle poles during mitosis (PubMed:26929214). {ECO:0000250|UniProtKB:Q8K0T4, ECO:0000269|PubMed:26929214}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |