| Gene Information | |
|---|---|
| Gene Name | NP95 |
| Organism | Homo sapiens (Human) |
| Gene Length | 793 |
| Protein Names | E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Inverted CCAAT box-binding protein of 90 kDa) (Nuclear protein 95) (Nuclear zinc finger protein Np95) (HuNp95) (hNp95) (RING finger protein 106) (RING-type E3 ubiquitin transferase UHRF1) (Transcription factor ICBP90) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (hUHRF1) (Ubiquitin-like-containing PHD and RING finger domains protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q96T88 |
| Gene Card | UHRF1 |
| Uniprot ID | Q96T88 |
| Pfam | PF00628; PF02182; PF12148; PF00240 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in thymus, bone marrow, testis, lung and heart. Overexpressed in breast cancer. {ECO:0000269|PubMed:10646863, ECO:0000269|PubMed:12838312, ECO:0000269|PubMed:15361834}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2FAZ (X-ray 2.00A ) 2L3R (NMR - ) 2LGG (NMR - ) 2LGK (NMR - ) 2LGL (NMR - ) 2PB7 (X-ray 1.90A ) 3ASK (X-ray 2.90A ) 3ASL (X-ray 1.41A ) 3BI7 (X-ray 1.70A ) 3CLZ (X-ray 2.20A ) 3DB3 (X-ray 2.40A ) 3DB4 (X-ray 2.40A ) 3DWH (X-ray 1.95A ) 3FL2 (X-ray 1.75A ) 3SHB (X-ray 1.80A ) 3SOU (X-ray 1.80A ) 3SOW (X-ray 1.95A ) 3SOX (X-ray 2.65A ) 3T6R (X-ray 1.95A ) 3ZVY (X-ray 1.95A ) 3ZVZ (X-ray 1.45A ) 4GY5 (X-ray 2.96A ) 4QQD (X-ray 2.28A ) 5C6D (X-ray 2.29A ) 5IAY (NMR - ) 5XPI (X-ray 2.20A ) 5YY9 (X-ray 2.65A ) 5YYA (X-ray 1.70A ) 6B9M (X-ray 1.68A ) 6IIW (X-ray 1.70A ) 6VCS (X-ray 1.70A ) 6VED (NMR - ) 6VYJ (X-ray 1.39A ) 6W92 (X-ray 1.30A ) 7FB7 (X-ray 1.45A ) |
| DBSNP | rs17886098 rs17885791 rs2307209 rs17884843 rs17883563 |
| Subcellular location [CC] | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00358, ECO:0000269|PubMed:10646863, ECO:0000269|PubMed:17673620, ECO:0000269|PubMed:17967883, ECO:0000269|PubMed:19056828, ECO:0000269|PubMed:21777816, ECO:0000269|PubMed:30335751}. Note=Localizes to replication foci. Enriched in pericentric heterochromatin. Also localizes to euchromatic regions. |
| Mouse PG classification | NA |
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