| Gene Information | |
|---|---|
| Gene Name | SLC7A11 |
| Organism | Homo sapiens (Human) |
| Gene Length | 501 |
| Protein Names | Cystine/glutamate transporter (Amino acid transport system xc-) (Calcium channel blocker resistance protein CCBR1) (Solute carrier family 7 member 11) (xCT) |
| Target Name | cystine/glutamate transporter |
| Target Type | Clinical trial target |
| Gene Age | >4290 ( ENSG00000151012 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9UPY5 |
| Gene Card | SLC7A11 |
| Uniprot ID | Q9UPY5 |
| Pfam | PF13520 |
| In ASD | no |
| Allosteric Prediction | yes (0.632821694) |
| Ortholog in Animals | Alpaca_ SLC7A11 ( ortholog_one2one ) Dog_ SLC7A11 ( ortholog_one2one ) GuineaPig_ SLC7A11 ( ortholog_one2one ) Macaque_ SLC7A11 ( ortholog_one2one ) Mouse_ Slc7a11 ( ortholog_one2one ) Pig_ SLC7A11 ( ortholog_one2one ) Rat_ Slc7a11 ( ortholog_one2one ) Rabbit_ SLC7A11 ( ortholog_one2one ) |
| Ohnologs | SLC7A5 |
| Paralogs | SLC7A6, SLC7A10, SLC7A9, SLC7A8, SLC7A13, SLC7A14, SLC7A7, SLC7A3, SLC7A2, SLC7A4, SLC7A1, SLC7A5 |
| Tissue | brain, cerebral.cortex |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7CCS (EM 6.20A ) 7EPZ (EM 3.40A ) 7P9U (EM 3.70A ) 7P9V (EM 3.40A ) |
| DBSNP | NA |
| Subcellular location [CC] | Membrane {ECO:0000269|PubMed:15151999}; Multi-pass membrane protein {ECO:0000269|PubMed:15151999}. |
| Mouse PG classification | NA |
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