| Gene Information | |
|---|---|
| Gene Name | MTHFD1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 935 |
| Protein Names | C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) (Epididymis secretory sperm binding protein) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)] |
| Target Name | c-1-tetrahydrofolate synthase, cytoplasmic |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000100714 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P11586 |
| Gene Card | MTHFD1 |
| Uniprot ID | P11586 |
| Pfam | PF01268; PF00763; PF02882 |
| In ASD | no |
| Allosteric Prediction | yes (0.612500565) |
| Ortholog in Animals | Alpaca_ MTHFD1 ( ortholog_one2one ) Alpaca_ MTHFD1 ( ortholog_one2many ) Dog_ MTHFD1 ( ortholog_one2many ) GuineaPig_ MTHFD1 ( ortholog_one2one ) Macaque_ MTHFD1 ( ortholog_one2one ) Mouse_ Mthfd1 ( ortholog_one2one ) Pig_ MTHFD1 ( ortholog_one2one ) Rat_ Mthfd1 ( ortholog_one2one ) Rabbit_ MTHFD1 ( ortholog_one2one ) |
| Ohnologs | MTHFD1L |
| Paralogs | MTHFD2L, MTHFD1L, MTHFD2 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1A4I (X-ray 1.50A ) 1DIA (X-ray 2.20A ) 1DIB (X-ray 2.70A ) 1DIG (X-ray 2.20A ) 6ECP (X-ray 2.20A ) 6ECQ (X-ray 2.70A ) 6ECR (X-ray 2.20A ) |
| DBSNP | rs370444838 rs1555336810 rs1950902 rs4902283 rs141210410 rs771978838 rs34181110 rs2236225 rs10813 rs17857382 |
| Subcellular location [CC] | Cytoplasm {ECO:0000305|PubMed:3053686}. |
| Mouse PG classification | NA |
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