Gene Information
Gene NameNOS2
OrganismHomo sapiens (Human)
Gene Length1153
Protein NamesNitric oxide synthase, inducible (EC 1.14.13.39) (Hepatocyte NOS) (HEP-NOS) (Inducible NO synthase) (Inducible NOS) (iNOS) (NOS type II) (Peptidyl-cysteine S-nitrosylase NOS2)
Target Namenitric-oxide synthase inducible
Target TypeClinical trial target
Gene Age544 ( ENSG00000007171 )
Evolutionary StageEuk+Bac
AlphaFoldDBP35228
Gene CardNOS2
Uniprot IDP35228
PfamPF00667; PF00258; PF00175; PF02898
In ASDno
Allosteric Predictionyes (1.904724304)
Ortholog in AnimalsAlpaca_ NOS2 ( ortholog_one2one )
Dog_ NOS2 ( ortholog_one2one )
GuineaPig_ NOS2 ( ortholog_one2one )
Macaque_ NOS2 ( ortholog_one2one )
Mouse_ Nos2 ( ortholog_one2one )
Pig_ NOS2 ( ortholog_one2one )
Rat_ Nos2 ( ortholog_one2one )
Rabbit_ NOS2 ( ortholog_one2one )
OhnologsNOS1
ParalogsPOR, MTRR, NOS1, NDOR1, NOS3
Tissueappendix, duodenum, small.intestine, rectum
Tissue SpecificityExpressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets. Expressed in chondrocytes (PubMed:7504305). {ECO:0000269|PubMed:7504305}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.044444(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1NSI  (X-ray  2.55A  )  2LL6  (NMR  -  )  2NSI  (X-ray  3.00A  )  3E7G  (X-ray  2.20A  )  3EJ8  (X-ray  2.55A  )  3HR4  (X-ray  2.50A  )  4CX7  (X-ray  3.16A  )  4NOS  (X-ray  2.25A  )  5TP6  (NMR  -  )  5XN3  (X-ray  1.34A  )  6JWM  (X-ray  1.23A  )  6JWN  (X-ray  1.61A  )  6KEY  (X-ray  1.24A  ) 
DBSNP rs3730017  rs2297518  rs769900089  rs28944173  rs28944201 
Subcellular location [CC]Cytoplasm, cytosol {ECO:0000269|PubMed:21199876}. Note=Localizes as discrete foci scattered throughout the cytosol and in the presence of SPSB1 and SPSB4, exhibits a more diffuse cytosolic localization. {ECO:0000269|PubMed:21199876}.
Mouse PG classificationHPG
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