| Gene Information | |
|---|---|
| Gene Name | NOS1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 292 |
| Protein Names | Nanos homolog 1 (NOS-1) (EC_Rep1a) |
| Target Name | nitric-oxide synthase brain |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000089250 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q8WY41 |
| Gene Card | NANOS1 |
| Uniprot ID | Q8WY41 |
| Pfam | PF05741 |
| In ASD | no |
| Allosteric Prediction | yes (2.304509569) |
| Ortholog in Animals | Alpaca_ NOS1 ( ortholog_one2one ) Dog_ NOS1 ( ortholog_one2one ) GuineaPig_ NOS1 ( ortholog_one2one ) Macaque_ NOS1 ( ortholog_one2one ) Mouse_ Nos1 ( ortholog_one2one ) Pig_ NOS1 ( ortholog_one2one ) Rat_ Nos1 ( ortholog_one2one ) |
| Ohnologs | NOS2, NOS3 |
| Paralogs | POR, MTRR, NDOR1, NOS2, NOS3 |
| Tissue | NA |
| Tissue Specificity | Testis and ovary (at protein level). Predominantly expressed in testis. Specifically expressed during germline development. In adult tissues, it is mainly expressed in spermatogonia, the stem cells of the germline. Also expressed during meiosis in spermatocytes. Not present in late, post-meiotic stage germ cells. Expressed in fetal ovaries, while it is weakly or not expressed in mature postmeiotic oocytes, suggesting that it may be expressed in premeiotic female germ cells. Expressed at high levels only in the E-cadherin deficient cell lines. Highly expressed in lung carcinomas and mostly detected in invasive tumor cells and its expression correlates with tumor aggressiveness. {ECO:0000269|PubMed:12690449, ECO:0000269|PubMed:17047063, ECO:0000269|PubMed:18223680, ECO:0000269|PubMed:19168546, ECO:0000269|PubMed:21421998}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.003847(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4CQO (X-ray 2.80A ) |
| DBSNP | rs191267549 rs538539239 rs587777767 rs587777768 |
| Subcellular location [CC] | Cytoplasm, perinuclear region {ECO:0000269|PubMed:12690449, ECO:0000269|PubMed:17047063, ECO:0000269|PubMed:19168546}. Cytoplasm {ECO:0000269|PubMed:12690449, ECO:0000269|PubMed:17047063, ECO:0000269|PubMed:19168546}. Note=Colocalizes with SNAPIN and PUM2 in the perinuclear region of germ cells. {ECO:0000269|PubMed:12690449, ECO:0000269|PubMed:19168546}. |
| Mouse PG classification | NA |
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