| Gene Information | |
|---|---|
| Gene Name | NOS1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1434 |
| Protein Names | Nitric oxide synthase, brain (EC 1.14.13.39) (Constitutive NOS) (NC-NOS) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Peptidyl-cysteine S-nitrosylase NOS1) (bNOS) |
| Target Name | nitric-oxide synthase brain |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000089250 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P29475 |
| Gene Card | NOS1 |
| Uniprot ID | P29475 |
| Pfam | PF00667; PF00258; PF00175; PF02898; PF00595 |
| In ASD | no |
| Allosteric Prediction | yes (2.304509569) |
| Ortholog in Animals | Alpaca_ NOS1 ( ortholog_one2one ) Dog_ NOS1 ( ortholog_one2one ) GuineaPig_ NOS1 ( ortholog_one2one ) Macaque_ NOS1 ( ortholog_one2one ) Mouse_ Nos1 ( ortholog_one2one ) Pig_ NOS1 ( ortholog_one2one ) Rat_ Nos1 ( ortholog_one2one ) |
| Ohnologs | NOS2, NOS3 |
| Paralogs | POR, MTRR, NDOR1, NOS2, NOS3 |
| Tissue | NA |
| Tissue Specificity | Isoform 1 is ubiquitously expressed: detected in skeletal muscle and brain, also in testis, lung and kidney, and at low levels in heart, adrenal gland and retina. Not detected in the platelets. Isoform 3 is expressed only in testis. Isoform 4 is detected in testis, skeletal muscle, lung, and kidney, at low levels in the brain, but not in the heart and adrenal gland. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001990(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 4D1N (X-ray 2.03A ) 4UCH (X-ray 2.20A ) 4UH5 (X-ray 1.98A ) 4UH6 (X-ray 1.98A ) 4V3U (X-ray 2.30A ) 5ADF (X-ray 1.97A ) 5ADG (X-ray 1.98A ) 5ADI (X-ray 2.20A ) 5FVU (X-ray 2.22A ) 5FVV (X-ray 2.05A ) 5FVW (X-ray 2.20A ) 5FVX (X-ray 2.30A ) 5UO1 (X-ray 1.90A ) 5UO2 (X-ray 1.95A ) 5UO3 (X-ray 2.20A ) 5UO4 (X-ray 2.00A ) 5UO5 (X-ray 2.00A ) 5UO6 (X-ray 1.96A ) 5UO7 (X-ray 2.06A ) 5VUV (X-ray 1.98A ) 5VUW (X-ray 2.03A ) 5VUX (X-ray 2.30A ) 5VUY (X-ray 2.15A ) 5VUZ (X-ray 1.97A ) 5VV0 (X-ray 1.80A ) 5VV1 (X-ray 1.95A ) 5VV2 (X-ray 2.00A ) 5VV3 (X-ray 2.18A ) 5VV4 (X-ray 2.10A ) 5VV5 (X-ray 2.15A ) 6AUY (X-ray 1.92A ) 6AUZ (X-ray 2.00A ) 6AV0 (X-ray 2.00A ) 6AV1 (X-ray 2.45A ) 6AV2 (X-ray 2.10A ) 6AV3 (X-ray 1.95A ) 6AV4 (X-ray 1.87A ) 6AV5 (X-ray 1.90A ) 6CIC (X-ray 1.75A ) 6CID (X-ray 1.75A ) 6NG1 (X-ray 2.15A ) 6NG2 (X-ray 1.93A ) 6NG4 (X-ray 1.78A ) 6NG5 (X-ray 1.96A ) 6NG6 (X-ray 2.04A ) 6NG7 (X-ray 2.00A ) 6NG8 (X-ray 1.90A ) 6NGA (X-ray 1.98A ) 6NGB (X-ray 1.90A ) 6NGC (X-ray 2.00A ) 6NGD (X-ray 1.80A ) 6NGE (X-ray 2.10A ) 6NGF (X-ray 1.99A ) 6NGH (X-ray 2.00A ) 6NGI (X-ray 1.80A ) 6NHB (X-ray 2.03A ) 6NHC (X-ray 2.16A ) 6PNA (X-ray 1.95A ) 6PNB (X-ray 2.05A ) 6PNC (X-ray 2.15A ) 6PND (X-ray 2.40A ) 6PNE (X-ray 2.10A ) 6PNF (X-ray 2.10A ) 6PNG (X-ray 1.77A ) 6PNH (X-ray 1.85A ) 6PO5 (X-ray 1.82A ) 6PO7 (X-ray 1.95A ) 6PO8 (X-ray 1.90A ) 6PO9 (X-ray 1.81A ) 6POA (X-ray 1.81A ) 6POB (X-ray 1.95A ) 6POC (X-ray 2.00A ) 6POT (X-ray 2.30A ) 7TS1 (X-ray 2.06A ) 7TS2 (X-ray 1.98A ) 7TS3 (X-ray 2.10A ) 7TS4 (X-ray 1.85A ) 7TS5 (X-ray 1.84A ) 7TS6 (X-ray 1.80A ) 7TS7 (X-ray 1.90A ) 7TS8 (X-ray 2.30A ) 7UAM (X-ray 1.84A ) 7US7 (X-ray 1.93A ) 7US8 (X-ray 1.82A ) |
| DBSNP | rs9658279 rs9658356 rs9658403 rs9658445 rs9658482 |
| Subcellular location [CC] | Cell membrane, sarcolemma; Peripheral membrane protein. Cell projection, dendritic spine {ECO:0000250}. Note=In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex. In neurons, enriched in dendritic spines (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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