| Gene Information | |
|---|---|
| Gene Name | NONO |
| Organism | Homo sapiens (Human) |
| Gene Length | 471 |
| Protein Names | Non-POU domain-containing octamer-binding protein (NonO protein) (54 kDa nuclear RNA- and DNA-binding protein) (p54(nrb)) (p54nrb) (55 kDa nuclear protein) (NMT55) (DNA-binding p52/p100 complex, 52 kDa subunit) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000147140 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q15233 |
| Gene Card | NONO |
| Uniprot ID | Q15233 |
| Pfam | PF08075; PF00076 |
| In ASD | no |
| Allosteric Prediction | no (-0.328053278) |
| Ortholog in Animals | Alpaca_ NONO ( ortholog_one2one ) Dog_ NONO ( ortholog_one2one ) Macaque_ NONO ( ortholog_one2one ) Mouse_ Nono ( ortholog_one2one ) Pig_ NONO ( ortholog_one2one ) Rat_ Nono ( ortholog_one2one ) |
| Ohnologs | SFPQ, PSPC1 |
| Paralogs | RAVER2, RBM15B, SPEN, RAVER1, SFPQ, PSPC1, RBM15 |
| Tissue | NA |
| Tissue Specificity | Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Also found in a number of breast tumor cell lines. {ECO:0000269|PubMed:9341872}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.009340(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3SDE (X-ray 1.90A ) 5IFM (X-ray 2.60A ) 6WMZ (X-ray 2.85A ) 7LRQ (X-ray 2.30A ) 7LRU (X-ray 1.60A ) 7PU5 (X-ray 3.00A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:22416126, ECO:0000269|PubMed:28712728}. Nucleus, nucleolus. Nucleus speckle {ECO:0000269|PubMed:22416126, ECO:0000269|PubMed:28712728}. Chromosome {ECO:0000250|UniProtKB:Q99K48}. Note=Detected in punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles. {ECO:0000269|PubMed:22416126, ECO:0000269|PubMed:28712728}. |
| Mouse PG classification | LPG |
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