Gene Information
Gene NameCARMIL1
OrganismHomo sapiens (Human)
Gene Length1371
Protein NamesF-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein regulator and myosin 1 linker protein 1) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A)
Target NameNA
Target TypeNA
Gene Age680 ( ENSG00000079691 )
Evolutionary StageEukaryota
AlphaFoldDBQ5VZK9
Gene CardCARMIL1
Uniprot IDQ5VZK9
PfamPF17888; PF16000; PF13516
In ASDno
Allosteric Predictionno (-0.448680496)
Ortholog in AnimalsAlpaca_ CARMIL1 ( ortholog_one2one )
Dog_ CARMIL1 ( ortholog_one2one )
GuineaPig_ CARMIL1 ( ortholog_one2one )
Macaque_ CARMIL1 ( ortholog_one2one )
Mouse_ Carmil1 ( ortholog_one2one )
Pig_ CARMIL1 ( ortholog_one2one )
Rat_ Carmil1 ( ortholog_one2one )
Rabbit_ CARMIL1 ( ortholog_one2one )
OhnologsCARMIL2, CARMIL3
ParalogsCARMIL3, PPP1R37, RNH1, CARMIL2
TissueNA
Tissue SpecificityExpressed in lung, placenta, small intestine, liver, thymus, colon, skeletal muscle, heart and brain. Higher expression in kidney. {ECO:0000269|PubMed:16054028}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3LK2  (X-ray  2.20A  )  3LK3  (X-ray  2.68A  ) 
DBSNP rs9358856  rs12207840  rs7454756  rs9885914 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:19846667}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q6EDY6}. Cell membrane {ECO:0000269|PubMed:26578515}. Cell projection, lamellipodium {ECO:0000269|PubMed:19846667}. Note=Found on macropinosomes (PubMed:19846667). Colocalized with heterodimeric capping protein (CP) and F-actin in lamellipodia but not with F-actin in stress fibers (PubMed:19846667). {ECO:0000269|PubMed:19846667}.
Mouse PG classificationNA
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