Gene Information
Gene NameNOGO
OrganismHomo sapiens (Human)
Gene Length1192
Protein NamesReticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBQ9NQC3
Gene CardRTN4
Uniprot IDQ9NQC3
PfamPF02453
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityIsoform A: is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform B: widely expressed except for the liver. Highly expressed in endothelial cells and vascular smooth muscle cells, including blood vessels and mesenteric arteries (PubMed:15034570, PubMed:21183689). Isoform C: is expressed in brain, skeletal muscle and adipocytes. Isoform D is testis-specific. {ECO:0000269|PubMed:15034570, ECO:0000269|PubMed:21183689}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.008696(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2G31  (NMR  -  )  2JV5  (NMR  -  ) 
DBSNP rs11677099  rs6757519  rs6757705 
Subcellular location [CC][Isoform A]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26906412, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:27786289};
Multi-pass membrane protein {ECO:0000255}. Cell membrane;
Multi-pass membrane protein {ECO:0000255};
Cytoplasmic side {ECO:0000269|PubMed:27786289}. Note=Anchored to the membrane of the endoplasmic reticulum (ER) through 2 putative transmembrane domains. Localizes throughout the ER tubular network (PubMed:27619977). Co-localizes with TMEM33 at the ER sheets. {ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:27619977}.;
[Isoform B]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:27786289};
Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:15034570};
Multi-pass membrane protein {ECO:0000255};
Extracellular side {ECO:0000269|PubMed:15034570}. Cell junction {ECO:0000269|PubMed:21183689}. Note=Mainly located on endoplasmic reticulum tubules and sheet edges (PubMed:27786289). Upon ICAM1 engagement, redistributed toward endothelial junctions where interacts with CDH5 (PubMed:21183689). {ECO:0000269|PubMed:21183689, ECO:0000269|PubMed:27786289}.;
[Isoform C]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:25612671};
Multi-pass membrane protein {ECO:0000255}.
Mouse PG classificationNA
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