| Gene Information | |
|---|---|
| Gene Name | NOD2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1040 |
| Protein Names | Nucleotide-binding oligomerization domain-containing protein 2 (Caspase recruitment domain-containing protein 15) (Inflammatory bowel disease protein 1) |
| Target Name | nucleotide-binding oligomerization domain-containing protein 2 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000167207 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9HC29 |
| Gene Card | NOD2 |
| Uniprot ID | Q9HC29 |
| Pfam | PF00619; PF13516; PF05729; PF17776; PF17779 |
| In ASD | no |
| Allosteric Prediction | no (-0.246101782) |
| Ortholog in Animals | Alpaca_ NOD2 ( ortholog_one2one ) Dog_ NOD2 ( ortholog_one2one ) GuineaPig_ NOD2 ( ortholog_one2one ) Macaque_ NOD2 ( ortholog_one2one ) Mouse_ Nod2 ( ortholog_one2one ) Pig_ NOD2 ( ortholog_one2one ) Rat_ Nod2 ( ortholog_one2one ) Rabbit_ NOD2 ( ortholog_one2one ) |
| Ohnologs | NLRC3, NOD1 |
| Paralogs | NLRP9, NLRC5, NLRP14, NLRP7, NLRP4, CIITA, NOD1, NLRP8, NLRP10, NLRP3, NLRP5, NLRP6, NLRP11, NLRP2, PYDC2, NLRC3, NLRX1, NLRP12, NLRP13, NLRP1 |
| Tissue | NA |
| Tissue Specificity | Mainly expressed in monocytes (PubMed:11087742). Expressed also in intestinal mucosa, mainly in Paneth cells and, at lower extent, in the glandular epithelium (PubMed:22700971). {ECO:0000269|PubMed:11087742, ECO:0000269|PubMed:22700971}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.018182(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs34936594 rs104895468 rs34684955 rs104895420 rs61755182 rs104895422 rs104895423 rs2066842 rs5743271 rs104895424 rs104895425 rs104895426 rs104895427 rs104895461 rs104895462 rs104895428 rs5743272 rs104895469 rs104895470 rs145293873 rs104895476 rs104895493 rs104895477 rs104895481 rs104895429 rs104895431 rs2076754 rs104895432 rs104895482 rs104895492 rs104895460 rs1078327 rs104895494 rs104895480 rs104895478 rs104895472 rs104895473 rs104895471 rs104895479 rs104895474 rs104895438 rs104895439 rs104895475 rs5743276 rs2066844 rs5743277 rs104895440 rs104895483 rs5743278 rs61747625 rs104895442 rs3813758 rs104895443 rs5743279 rs62029861 rs104895484 rs104895444 rs104895485 rs104895445 rs104895486 rs104895467 rs104895446 rs104895447 rs2066845 rs104895452 rs104895453 rs5743291 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:31649195}. Cytoplasm {ECO:0000269|PubMed:19701189, ECO:0000269|PubMed:24790089, ECO:0000269|PubMed:25093298}. Membrane {ECO:0000269|PubMed:25093298}. Mitochondrion {ECO:0000269|PubMed:19701189}. Basolateral cell membrane {ECO:0000269|PubMed:16203728}. |
| Mouse PG classification | LPG |
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