| Gene Information | |
|---|---|
| Gene Name | NOD1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 953 |
| Protein Names | Nucleotide-binding oligomerization domain-containing protein 1 (Caspase recruitment domain-containing protein 4) |
| Target Name | pattern recognition receptor nod1 |
| Target Type | Literature-reported target |
| Gene Age | 544 ( ENSG00000106100 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9Y239 |
| Gene Card | NOD1 |
| Uniprot ID | Q9Y239 |
| Pfam | PF00619; PF13516; PF05729; PF17776; PF17779 |
| In ASD | no |
| Allosteric Prediction | yes (0.69068554) |
| Ortholog in Animals | Alpaca_ NOD1 ( ortholog_one2one ) Dog_ NOD1 ( ortholog_one2one ) GuineaPig_ NOD1 ( ortholog_one2one ) Macaque_ NOD1 ( ortholog_one2one ) Mouse_ Nod1 ( ortholog_one2one ) Rat_ Nod1 ( ortholog_one2one ) Rabbit_ NOD1 ( ortholog_one2one ) |
| Ohnologs | NLRC5, NOD2 |
| Paralogs | NLRP9, NLRC5, NLRP14, NLRP7, NLRP4, CIITA, NLRP8, NLRP10, NLRP3, NLRP5, NLRP6, NLRP11, NLRP2, PYDC2, NLRC3, NLRX1, NLRP12, NLRP13, NLRP1, NOD2 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in adult heart, skeletal muscle, pancreas, spleen and ovary. Also detected in placenta, lung, liver, kidney, thymus, testis, small intestine and colon. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);0.002101(Rat);0.044444(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2B1W (NMR - ) 2DBD (NMR - ) 2NSN (X-ray 2.00A ) 2NZ7 (X-ray 1.90A ) 4E9M (X-ray 2.15A ) 4JQW (X-ray 2.90A ) |
| DBSNP | rs2075820 rs5743342 rs2975634 rs5743345 rs5743346 |
| Subcellular location [CC] | Cytoplasm. Cell membrane {ECO:0000269|PubMed:31649195}. Apical cell membrane. Basolateral cell membrane. Note=Detected in the cytoplasm and at the cell membrane. Following bacterial infection, localizes to bacterial entry sites in the cell membrane. Recruited to the basolateral and apical membranes in polarized epithelial cells. |
| Mouse PG classification | NA |
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