| Gene Information | |
|---|---|
| Gene Name | PTGDR2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 395 |
| Protein Names | Prostaglandin D2 receptor 2 (Chemoattractant receptor-homologous molecule expressed on Th2 cells) (G-protein coupled receptor 44) (CD antigen CD294) |
| Target Name | prostaglandin d2 receptor 2 |
| Target Type | Clinical trial target |
| Gene Age | 244 ( ENSG00000183134 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9Y5Y4 |
| Gene Card | PTGDR2 |
| Uniprot ID | Q9Y5Y4 |
| Pfam | PF00001 |
| In ASD | no |
| Allosteric Prediction | yes (1.024565209) |
| Ortholog in Animals | Alpaca_ PTGDR2 ( ortholog_one2one ) Dog_ PTGDR2 ( ortholog_one2one ) GuineaPig_ PTGDR2 ( ortholog_one2one ) Macaque_ PTGDR2 ( ortholog_one2one ) Mouse_ Ptgdr2 ( ortholog_one2one ) Pig_ PTGDR2 ( ortholog_one2one ) Rat_ Ptgdr2 ( ortholog_one2one ) Rabbit_ PTGDR2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SSTR5, SSTR4, NPBWR1, OPRL1, GPR149, OPRM1, OPRK1, SSTR3, CMKLR2, SSTR1, LTB4R, LTB4R2, KISS1R, UTS2R, NPBWR2, SSTR2, OPRD1 |
| Tissue | NA |
| Tissue Specificity | Widespread expression. High expression in stomach, small intestine, heart and thymus. Intermediate expression in colon, spinal cord and peripheral blood and low expression in brain, skeletal muscle and spleen. Expressed also on Th2- and Tc2- type cells, eosinophils and basophils. {ECO:0000269|PubMed:11168006, ECO:0000269|PubMed:11208866, ECO:0000269|PubMed:12466225, ECO:0000269|PubMed:9973380}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6D26 (X-ray 2.80A ) 6D27 (X-ray 2.74A ) 7M8W (X-ray 2.61A ) |
| DBSNP | rs2467642 |
| Subcellular location [CC] | Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Internalized receptors colocalized with RAB11A. {ECO:0000269|PubMed:17207480}. |
| Mouse PG classification | NA |
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