| Gene Information | |
|---|---|
| Gene Name | NNT |
| Organism | Homo sapiens (Human) |
| Gene Length | 1086 |
| Protein Names | NAD(P) transhydrogenase, mitochondrial (EC 7.1.1.1) (Nicotinamide nucleotide transhydrogenase) (Pyridine nucleotide transhydrogenase) |
| Target Name | nad(p) transhydrogenase, mitochondrial |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000112992 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q13423 |
| Gene Card | NNT |
| Uniprot ID | Q13423 |
| Pfam | PF01262; PF05222; PF02233; PF12769 |
| In ASD | no |
| Allosteric Prediction | yes (0.481381279) |
| Ortholog in Animals | Alpaca_ NNT ( ortholog_one2one ) Dog_ NNT ( ortholog_one2one ) GuineaPig_ NNT ( ortholog_one2one ) Macaque_ NNT ( ortholog_one2one ) Mouse_ Nnt ( ortholog_one2many ) Pig_ NNT ( ortholog_one2one ) Rat_ Nnt ( ortholog_one2one ) Rabbit_ NNT ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed with expression most readily detectable in adrenal, heart, kidney, thyroid and adipose tissues. {ECO:0000269|PubMed:22634753}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1DJL (X-ray 2.00A ) 1PT9 (X-ray 2.42A ) 1U31 (X-ray 2.20A ) |
| DBSNP | rs867004061 rs1447408865 rs781183677 rs387907232 rs371979800 rs1474421419 rs387907233 rs387907234 rs370273690 |
| Subcellular location [CC] | Mitochondrion inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}; Matrix side {ECO:0000305}. |
| Mouse PG classification | NA |
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