Gene Information
Gene NameNMNAT2
OrganismHomo sapiens (Human)
Gene Length307
Protein NamesNicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 (NMN/NaMN adenylyltransferase 2) (EC 2.7.7.1) (EC 2.7.7.18) (Nicotinamide mononucleotide adenylyltransferase 2) (NMN adenylyltransferase 2) (Nicotinate-nucleotide adenylyltransferase 2) (NaMN adenylyltransferase 2)
Target NameNA
Target TypeNA
Gene Age680 ( ENSG00000157064 )
Evolutionary StageVertebrata
AlphaFoldDBQ9BZQ4
Gene CardNMNAT2
Uniprot IDQ9BZQ4
PfamPF01467
In ASDno
Allosteric Predictionyes (0.070766355)
Ortholog in AnimalsAlpaca_ NMNAT2 ( ortholog_one2one )
Dog_ NMNAT2 ( ortholog_one2one )
GuineaPig_ NMNAT2 ( ortholog_one2one )
Macaque_ NMNAT2 ( ortholog_one2one )
Mouse_ Nmnat2 ( ortholog_one2one )
Pig_ NMNAT2 ( ortholog_one2one )
Rat_ Nmnat2 ( ortholog_one2one )
OhnologsNA
ParalogsNMNAT1, NMNAT3
Tissuecerebral.cortex
Tissue SpecificityHighly expressed in brain, in particular in cerebrum, cerebellum, occipital lobe, frontal lobe, temporal lobe and putamen. Also found in the heart, skeletal muscle, pancreas and islets of Langerhans. {ECO:0000269|PubMed:12359228, ECO:0000269|PubMed:14516279, ECO:0000269|PubMed:16118205}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP NA 
Subcellular location [CC]Golgi apparatus membrane {ECO:0000269|PubMed:16118205};
Lipid-anchor {ECO:0000250|UniProtKB:Q8BNJ3}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q8BNJ3};
Lipid-anchor {ECO:0000250|UniProtKB:Q8BNJ3}. Cytoplasm {ECO:0000269|PubMed:16118205}. Cell projection, axon {ECO:0000250|UniProtKB:Q8BNJ3}. Note=Delivered to axons with Golgi-derived cytoplasmic vesicles. {ECO:0000250|UniProtKB:Q8BNJ3}.
Mouse PG classificationNA
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