| Gene Information | |
|---|---|
| Gene Name | NME4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 187 |
| Protein Names | Nucleoside diphosphate kinase, mitochondrial (NDK) (NDP kinase, mitochondrial) (EC 2.7.4.6) (Nucleoside diphosphate kinase D) (NDPKD) (nm23-H4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000103202 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | O00746 |
| Gene Card | NME4 |
| Uniprot ID | O00746 |
| Pfam | PF00334 |
| In ASD | no |
| Allosteric Prediction | no (-0.347352993) |
| Ortholog in Animals | Alpaca_ NME4 ( ortholog_one2one ) GuineaPig_ NME4 ( ortholog_one2one ) Macaque_ DECR2 ( ortholog_one2one ) Mouse_ Nme4 ( ortholog_one2one ) Pig_ NME4 ( ortholog_one2one ) Rabbit_ NME4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NME8, NME2, NME7, NME1, NME6, NME9, NME3, NME5 |
| Tissue | NA |
| Tissue Specificity | Widely distributed. Found at very high levels in prostate, heart, liver, small intestine, and skeletal muscle tissues, and in low amounts in the brain and in blood leukocytes. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1EHW (X-ray 2.40A ) |
| DBSNP | NA |
| Subcellular location [CC] | Mitochondrion intermembrane space {ECO:0000269|PubMed:18635542}; Peripheral membrane protein. Mitochondrion matrix {ECO:0000305|PubMed:18635542}. Note=Predominantly localized in the mitochondrion intermembrane space (PubMed:18635542). Colocalizes with OPA1 in mitochondria (PubMed:24970086). {ECO:0000269|PubMed:18635542, ECO:0000269|PubMed:24970086}. |
| Mouse PG classification | NA |
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