| Gene Information | |
|---|---|
| Gene Name | NME2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 152 |
| Protein Names | Nucleoside diphosphate kinase B (NDK B) (NDP kinase B) (EC 2.7.4.6) (C-myc purine-binding transcription factor PUF) (Histidine protein kinase NDKB) (EC 2.7.13.3) (nm23-H2) |
| Target Name | nucleoside diphosphate kinase b |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000243678 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P22392 |
| Gene Card | NME2 |
| Uniprot ID | P22392 |
| Pfam | PF00334 |
| In ASD | no |
| Allosteric Prediction | yes (0.455669471) |
| Ortholog in Animals | Alpaca_ NME2 ( ortholog_one2one ) GuineaPig_ NME2 ( ortholog_one2one ) Mouse_ Nme2 ( ortholog_one2one ) Rat_ Nme2 ( ortholog_one2many ) Rat_ AABR07044593.1 ( ortholog_one2many ) Rabbit_ NME2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NME8, NME7, NME1, NME4, NME6, NME9, NME3, NME5 |
| Tissue | NA |
| Tissue Specificity | [Isoform 1]: Ubiquitously expressed. {ECO:0000269|PubMed:16442775}.; [Isoform 3]: Ubiquitously expressed. {ECO:0000269|PubMed:16442775}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002126(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1NSK (X-ray 2.80A ) 1NUE (X-ray 2.00A ) 3BBB (X-ray 1.30A ) 3BBC (X-ray 1.70A ) 3BBF (X-ray 1.70A ) 7KPF (X-ray 2.23A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:17532299}. Cell projection, lamellipodium {ECO:0000269|PubMed:11919189}. Cell projection, ruffle {ECO:0000269|PubMed:11919189}. Note=Colocalizes with ITGB1 and ITGB1BP1 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen but not on vitronectin or laminin substrates. {ECO:0000269|PubMed:11919189}.; [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:16442775}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:16442775}. Nucleus {ECO:0000269|PubMed:16442775}.; [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:16442775}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:16442775}. Nucleus {ECO:0000269|PubMed:16442775}. |
| Mouse PG classification | NA |
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