| Gene Information | |
|---|---|
| Gene Name | NME1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 152 |
| Protein Names | Nucleoside diphosphate kinase A (NDK A) (NDP kinase A) (EC 2.7.4.6) (Granzyme A-activated DNase) (GAAD) (Metastasis inhibition factor nm23) (NM23-H1) (Tumor metastatic process-associated protein) |
| Target Name | nucleoside diphosphate kinase a |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000239672 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P15531 |
| Gene Card | NME1 |
| Uniprot ID | P15531 |
| Pfam | PF00334 |
| In ASD | no |
| Allosteric Prediction | yes (0.534498523) |
| Ortholog in Animals | Dog_ NME2 ( ortholog_one2many ) Dog_ NME1 ( ortholog_one2many ) GuineaPig_ NME1 ( ortholog_one2one ) Mouse_ Nme1 ( ortholog_one2one ) Pig_ NME1 ( ortholog_one2one ) Rat_ Nme1 ( ortholog_one2many ) Rabbit_ NME1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NME8, NME2, NME7, NME4, NME6, NME9, NME3, NME5 |
| Tissue | NA |
| Tissue Specificity | Isoform 1 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen and thymus. Expressed in lung carcinoma cell lines but not in normal lung tissues. Isoform 2 is ubiquitously expressed and its expression is also related to tumor differentiation. {ECO:0000269|PubMed:10512675, ECO:0000269|PubMed:12601555, ECO:0000269|PubMed:16442775}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.05974(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1JXV (X-ray 2.20A ) 1UCN (X-ray 2.00A ) 2HVD (X-ray 2.15A ) 2HVE (X-ray 2.40A ) 3L7U (X-ray 2.10A ) 4ENO (X-ray 2.80A ) 5UI4 (X-ray 2.75A ) |
| DBSNP | rs121917887 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:16442775}. Nucleus {ECO:0000269|PubMed:16442775}. Note=Cell-cycle dependent nuclear localization which can be induced by interaction with Epstein-barr viral proteins or by degradation of the SET complex by GzmA. |
| Mouse PG classification | NA |
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