| Gene Information | |
|---|---|
| Gene Name | NLRP9 |
| Organism | Homo sapiens (Human) |
| Gene Length | 991 |
| Protein Names | NACHT, LRR and PYD domains-containing protein 9 (Nucleotide-binding oligomerization domain protein 6) (PYRIN and NACHT-containing protein 12) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 132 ( ENSG00000185792 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q7RTR0 |
| Gene Card | NLRP9 |
| Uniprot ID | Q7RTR0 |
| Pfam | PF13516; PF05729; PF17776; PF17779; PF02758 |
| In ASD | no |
| Allosteric Prediction | no (-0.843489821) |
| Ortholog in Animals | Alpaca_ NLRP9 ( ortholog_one2one ) Dog_ NLRP9 ( ortholog_one2many ) Mouse_ Nlrp9a ( ortholog_one2many ) Mouse_ Nlrp9b ( ortholog_one2many ) Mouse_ Nlrp9c ( ortholog_one2many ) Pig_ NLRP9 ( ortholog_one2one ) Rat_ Nlrp9 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NLRC5, NLRP14, NLRP7, NLRP4, CIITA, NOD1, NLRP8, NLRP10, NLRP3, NLRP5, NLRP6, NLRP11, NLRP2, PYDC2, NLRC3, NLRX1, NLRP12, NLRP13, NLRP1, NOD2 |
| Tissue | NA |
| Tissue Specificity | Expressed in ileum intestinal epithelial cells. Not detected in peripheral blood mononuclear cells (PubMed:28636595). Expressed in cerebral endothelial cells and, at much lower levels, in brain pericytes (PubMed:28432035). {ECO:0000269|PubMed:28432035, ECO:0000269|PubMed:28636595}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6Z2G (X-ray 1.95A ) 7BSO (X-ray 2.08A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:Q66X22}. Inflammasome {ECO:0000269|PubMed:28636595}. |
| Mouse PG classification | NA |
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