| Gene Information | |
|---|---|
| Gene Name | NLRP12 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1061 |
| Protein Names | NACHT, LRR and PYD domains-containing protein 12 (Monarch-1) (PYRIN-containing APAF1-like protein 7) (Regulated by nitric oxide) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000142405 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P59046 |
| Gene Card | NLRP12 |
| Uniprot ID | P59046 |
| Pfam | PF14484; PF13516; PF05729; PF17776; PF17779; PF02758 |
| In ASD | no |
| Allosteric Prediction | no (-0.139707658) |
| Ortholog in Animals | Alpaca_ NLRP12 ( ortholog_one2one ) Dog_ NLRP12 ( ortholog_one2one ) Macaque_ NLRP12 ( ortholog_one2one ) Mouse_ Nlrp12 ( ortholog_one2one ) Pig_ NLRP12 ( ortholog_one2one ) Rat_ Nlrp12 ( ortholog_one2one ) Rabbit_ NLRP12 ( ortholog_one2one ) |
| Ohnologs | NLRC3 |
| Paralogs | NLRP9, NLRC5, NLRP14, NLRP7, NLRP4, CIITA, NOD1, NLRP8, NLRP10, NLRP3, NLRP5, NLRP6, NLRP11, NLRP2, PYDC2, NLRC3, NLRX1, NLRP13, NLRP1, NOD2 |
| Tissue | whole.blood |
| Tissue Specificity | Detected only in peripheral blood leukocytes, predominantly in eosinophils and granulocytes, and at lower levels in monocytes. {ECO:0000269|PubMed:11167794}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2L6A (NMR - ) 4XHS (X-ray 1.70A ) 5H7N (X-ray 1.85A ) |
| DBSNP | rs34436714 rs34971363 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:30902577}. |
| Mouse PG classification | LPG |
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