Gene Information
Gene NameNLRP10
OrganismHomo sapiens (Human)
Gene Length655
Protein NamesNACHT, LRR and PYD domains-containing protein 10 (Nucleotide-binding oligomerization domain protein 8)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000182261 )
3 ( ENSG00000276780 )
3 ( ENSG00000281166 )
Evolutionary StageMammalia
AlphaFoldDBQ86W26
Gene CardNLRP10
Uniprot IDQ86W26
PfamPF05729; PF17779; PF02758
In ASDno
Allosteric Predictionno (-0.464529158)
Ortholog in AnimalsAlpaca_ NLRP10 ( ortholog_one2one )
Dog_ NLRP10 ( ortholog_one2one )
Macaque_ NLRP10 ( ortholog_one2one )
Mouse_ Nlrp10 ( ortholog_one2one )
Rat_ Nlrp10 ( ortholog_one2one )
Rabbit_ NLRP10 ( ortholog_one2one )
OhnologsNA
ParalogsNLRP9, NLRC5, NLRP14, NLRP7, NLRP4, CIITA, NOD1, NLRP8, NLRP3, NLRP5, NLRP6, NLRP11, NLRP2, PYDC2, NLRC3, NLRX1, NLRP12, NLRP13, NLRP1, NOD2
TissueNA
Tissue SpecificityHighly expressed in basal and suprabasal epidermal cell layers with lower levels in dermal fibroblast cells (at protein level) (PubMed:22672233). Widely expressed with highest levels in heart, brain and skeletal muscle (PubMed:15096476). Also expressed in liver, colon, dermis and epidermis (PubMed:15096476). Little expression detected in myeloid cells or peripheral blood mononuclear cells (PubMed:15096476). {ECO:0000269|PubMed:15096476, ECO:0000269|PubMed:22672233}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2M5V  (NMR  -  ) 
DBSNP NA 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:22672233}. Cell membrane {ECO:0000269|PubMed:22672233};
Peripheral membrane protein {ECO:0000305}. Note=Cytoplasmic protein which is recruited to the cell membrane by NOD1 following invasive bacterial infection. {ECO:0000269|PubMed:22672233}.
Mouse PG classificationNA
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