| Gene Information | |
|---|---|
| Gene Name | HCN4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1203 |
| Protein Names | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000138622 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9Y3Q4 |
| Gene Card | HCN4 |
| Uniprot ID | Q9Y3Q4 |
| Pfam | PF00027; PF00520; PF08412 |
| In ASD | yes |
| Allosteric Prediction | yes (0.999993815) |
| Ortholog in Animals | Alpaca_ HCN4 ( ortholog_one2one ) Dog_ HCN4 ( ortholog_one2one ) GuineaPig_ HCN4 ( ortholog_one2one ) Macaque_ HCN4 ( ortholog_one2one ) Mouse_ Hcn4 ( ortholog_one2one ) Pig_ HCN4 ( ortholog_one2one ) Rat_ Hcn4 ( ortholog_one2one ) Rabbit_ HCN4 ( ortholog_one2one ) |
| Ohnologs | HCN2, HCN3, HCN1 |
| Paralogs | KCNH7, KCNH1, HCN3, CNGA3, KCNH3, HCN2, KCNH8, HCN1, CNGB3, CNGB1, CNGA1, KCNH6, KCNH2, KCNH4, CNGA2, CNGA4, KCNH5 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in thalamus, testis and in heart, both in ventricle and atrium. Detected at much lower levels in amygdala, substantia nigra, cerebellum and hippocampus. {ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10430953}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2MNG (NMR - ) 3OTF (X-ray 2.40A ) 3U11 (X-ray 2.50A ) 4HBN (X-ray 2.60A ) 4KL1 (X-ray 2.70A ) 4NVP (X-ray 2.50A ) 6GYN (EM 3.40A ) 6GYO (EM 3.40A ) |
| DBSNP | rs1454748709 rs104894485 rs104894488 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10430953, ECO:0000269|PubMed:16407510}; Multi-pass membrane protein {ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10430953, ECO:0000269|PubMed:16407510}. |
| Mouse PG classification | HPG |
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