| Gene Information | |
|---|---|
| Gene Name | NLRC4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1024 |
| Protein Names | NLR family CARD domain-containing protein 4 (CARD, LRR, and NACHT-containing protein) (CED-4-like protein Clan) (Caspase recruitment domain-containing protein 12) (Ice protease-activating factor) (Ipaf) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000091106 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9NPP4 |
| Gene Card | NLRC4 |
| Uniprot ID | Q9NPP4 |
| Pfam | PF00619; PF05729; PF17889 |
| In ASD | no |
| Allosteric Prediction | no (-0.085592332) |
| Ortholog in Animals | Alpaca_ NLRC4 ( ortholog_one2one ) GuineaPig_ NLRC4 ( ortholog_one2one ) Macaque_ NLRC4 ( ortholog_one2one ) Mouse_ Nlrc4 ( ortholog_one2one ) Rat_ Nlrc4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NAIP, BIRC2, BIRC3, XIAP, BIRC7, BIRC6, BIRC5 |
| Tissue | appendix, whole.blood |
| Tissue Specificity | Isoform 2 is expressed ubiquitously, although highly expressed in lung and spleen. Isoform 1 is highly expressed in lung, followed by leukocytes especially monocytes, lymph node, colon, brain, prostate, placenta, spleen, bone marrow and fetal liver. Isoform 4 is only detected in brain. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6K8J (EM 3.30A ) 6MKS (EM 3.40A ) 6N1I (EM 3.58A ) |
| DBSNP | rs587777840 rs587781260 rs606231460 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:11390368}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q3UP24}. Inflammasome {ECO:0000269|PubMed:15107016, ECO:0000269|PubMed:33420028}. |
| Mouse PG classification | LPG |
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