| Gene Information | |
|---|---|
| Gene Name | NLK1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 445 |
| Protein Names | Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (HSPK 21) (Never in mitosis A-related kinase 2) (NimA-related protein kinase 2) (NimA-like protein kinase 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P51955 |
| Gene Card | NEK2 |
| Uniprot ID | P51955 |
| Pfam | PF00069 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Isoform 1 and isoform 2 are expressed in peripheral blood T-cells and a wide variety of transformed cell types. Isoform 1 and isoform 4 are expressed in the testis. Up-regulated in various cancer cell lines, as well as primary breast tumors. {ECO:0000269|PubMed:11742531, ECO:0000269|PubMed:15659832}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002590(Rat);0.242627(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 2JAV (X-ray 2.20A ) 2W5A (X-ray 1.55A ) 2W5B (X-ray 2.40A ) 2W5H (X-ray 2.33A ) 2WQO (X-ray 2.17A ) 2XK3 (X-ray 2.20A ) 2XK4 (X-ray 2.10A ) 2XK6 (X-ray 2.20A ) 2XK7 (X-ray 1.99A ) 2XK8 (X-ray 2.00A ) 2XKC (X-ray 2.50A ) 2XKD (X-ray 1.96A ) 2XKE (X-ray 2.20A ) 2XKF (X-ray 2.35A ) 2XNM (X-ray 1.85A ) 2XNN (X-ray 2.50A ) 2XNO (X-ray 1.98A ) 2XNP (X-ray 1.98A ) 4A4X (X-ray 2.40A ) 4AFE (X-ray 2.60A ) 5M51 (X-ray 1.90A ) 5M53 (X-ray 1.90A ) 5M55 (X-ray 2.40A ) 5M57 (X-ray 2.30A ) 6SGD (X-ray 2.00A ) 6SGH (X-ray 3.00A ) 6SGI (X-ray 2.30A ) 6SGK (X-ray 2.00A ) 6SK9 (X-ray 2.00A ) 6TM5 (EM 3.90A ) |
| DBSNP | rs2230489 rs56102977 |
| Subcellular location [CC] | [Isoform 1]: Nucleus. Nucleus, nucleolus {ECO:0000269|PubMed:15161910}. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:26220856}. Cytoplasm, cytoskeleton, spindle pole. Chromosome, centromere, kinetochore. Chromosome, centromere {ECO:0000250}. Note=STK3/MST2 and SAV1 are required for its targeting to the centrosome. Colocalizes with SGO1 and MAD1L1 at the kinetochore. Not associated with kinetochore in the interphase but becomes associated with it upon the breakdown of the nuclear envelope. Has a nucleolar targeting/ retention activity via a coiled-coil domain at the C-terminal end.; [Isoform 2]: Cytoplasm. Note=Predominantly cytoplasmic.; [Isoform 4]: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Predominantly nuclear. |
| Mouse PG classification | NA |
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