| Gene Information | |
|---|---|
| Gene Name | SLC4A7 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1214 |
| Protein Names | Sodium bicarbonate cotransporter 3 (Electroneutral Na/HCO(3) cotransporter) (Sodium bicarbonate cotransporter 2) (Sodium bicarbonate cotransporter 2b) (Bicarbonate transporter) (Solute carrier family 4 member 7) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000033867 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9Y6M7 |
| Gene Card | SLC4A7 |
| Uniprot ID | Q9Y6M7 |
| Pfam | PF07565; PF00955 |
| In ASD | no |
| Allosteric Prediction | yes (0.141585311) |
| Ortholog in Animals | Alpaca_ SLC4A7 ( ortholog_one2one ) Dog_ SLC4A7 ( ortholog_one2one ) GuineaPig_ SLC4A7 ( ortholog_one2one ) Macaque_ SLC4A7 ( ortholog_one2one ) Mouse_ Slc4a7 ( ortholog_one2one ) Pig_ SLC4A7 ( ortholog_one2one ) Rat_ Slc4a7 ( ortholog_one2one ) Rabbit_ SLC4A7 ( ortholog_one2one ) |
| Ohnologs | SLC4A8, SLC4A10, SLC4A5 |
| Paralogs | SLC4A9, SLC4A3, SLC4A2, SLC4A4, SLC4A10, SLC4A5, SLC4A11, SLC4A1, SLC4A8 |
| Tissue | small.intestine |
| Tissue Specificity | Highly expressed in testis and spleen. Also expressed in retina, colon, small intestine, ovary, thymus, prostate, muscle, heart and kidney. {ECO:0000269|PubMed:9610397}.; [Isoform 1]: Expressed in skeletal muscle and heart muscle. {ECO:0000269|PubMed:10347222}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs3755652 |
| Subcellular location [CC] | Basolateral cell membrane {ECO:0000250|UniProtKB:Q9R1N3}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:Q9R1N3}; Multi-pass membrane protein {ECO:0000255}. Cell projection, stereocilium {ECO:0000250|UniProtKB:Q9R1N3}. Cell membrane {ECO:0000269|PubMed:14578046, ECO:0000269|PubMed:29779931}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to the stereocilia of cochlear outer hair cells and to the lateral membrane of cochlear inner hair cells (By similarity). {ECO:0000250|UniProtKB:Q9R1N3}.; [Isoform 6]: Cell membrane {ECO:0000269|PubMed:29779931}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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