| Gene Information | |
|---|---|
| Gene Name | NLGN2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 835 |
| Protein Names | Neuroligin-2 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000169992 ) 3 ( ENSG00000283859 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q8NFZ4 |
| Gene Card | NLGN2 |
| Uniprot ID | Q8NFZ4 |
| Pfam | PF00135 |
| In ASD | no |
| Allosteric Prediction | yes (0.472218783) |
| Ortholog in Animals | Alpaca_ NLGN2 ( ortholog_one2one ) Dog_ NLGN2 ( ortholog_one2one ) GuineaPig_ NLGN2 ( ortholog_one2one ) Macaque_ NLGN2 ( ortholog_one2one ) Mouse_ Nlgn2 ( ortholog_one2one ) Rat_ Nlgn2 ( ortholog_one2one ) Rabbit_ NLGN2 ( ortholog_one2one ) |
| Ohnologs | NLGN4Y, NLGN3, NLGN1, CES4A, CES2 |
| Paralogs | ACHE, NLGN4X, NLGN4Y, CES3, NLGN1, CES2, CES5A, CES4A, BCHE, TG, NLGN3, CES1, CEL |
| Tissue | NA |
| Tissue Specificity | Expressed in the blood vessel walls. Detected in colon, brain and pancreas islets of Langerhans (at protein level). Detected in brain, and at lower levels in pancreas islet beta cells. {ECO:0000269|PubMed:18755801, ECO:0000269|PubMed:19926856}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.005990(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 5XEQ (X-ray 3.14A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Postsynaptic cell membrane {ECO:0000250}. Presynaptic cell membrane {ECO:0000250}. Note=Detected at postsynaptic membranes in brain. Detected at dendritic spines in cultured neurons. Colocalizes with GPHN and ARHGEF9 at neuronal cell membranes (By similarity). Localized at presynaptic membranes in retina. Colocalizes with GABRG2 at inhibitory synapses in the retina (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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