| Gene Information | |
|---|---|
| Gene Name | NLGN1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 863 |
| Protein Names | Neuroligin-1 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000169760 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q8N2Q7 |
| Gene Card | NLGN1 |
| Uniprot ID | Q8N2Q7 |
| Pfam | PF00135 |
| In ASD | no |
| Allosteric Prediction | yes (0.327601561) |
| Ortholog in Animals | Alpaca_ NLGN1 ( ortholog_one2one ) Dog_ NLGN1 ( ortholog_one2one ) GuineaPig_ NLGN1 ( ortholog_one2one ) Macaque_ NLGN1 ( ortholog_one2one ) Mouse_ Nlgn1 ( ortholog_one2one ) Pig_ NLGN1 ( ortholog_one2one ) Rat_ Nlgn1 ( ortholog_one2one ) Rabbit_ NLGN1 ( ortholog_one2one ) |
| Ohnologs | NLGN4X, NLGN4Y, NLGN2, NLGN3 |
| Paralogs | NLGN2, ACHE, NLGN4X, NLGN4Y, CES3, CES2, CES5A, CES4A, BCHE, TG, NLGN3, CES1, CEL |
| Tissue | brain, testis |
| Tissue Specificity | Expressed in the blood vessel walls (at protein level). Highly expressed in brain through prenatal stages, and at lower levels in pancreas islet beta cells. {ECO:0000269|PubMed:18755801, ECO:0000269|PubMed:19926856, ECO:0000269|PubMed:28841651}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 5OJ6 (X-ray 3.30A ) 5OJK (X-ray 2.55A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:28841651}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q62765}. Postsynaptic density {ECO:0000250|UniProtKB:Q62765}. Synaptic cleft {ECO:0000250|UniProtKB:Q62765}. Synaptic cell membrane {ECO:0000250|UniProtKB:Q62765}. Note=Enriched in synaptic plasma membranes and clustered in synaptic clefts and postsynaptic densities. Colocalized with DLG4/PSD-95 and GRIN1/NMDAR1. {ECO:0000250|UniProtKB:Q62765}. |
| Mouse PG classification | NA |
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