| Gene Information | |
|---|---|
| Gene Name | NKX2-1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 371 |
| Protein Names | Homeobox protein Nkx-2.1 (Homeobox protein NK-2 homolog A) (Thyroid nuclear factor 1) (Thyroid transcription factor 1) (TTF-1) (Thyroid-specific enhancer-binding protein) (T/EBP) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000136352 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P43699 |
| Gene Card | NKX2-1 |
| Uniprot ID | P43699 |
| Pfam | PF00046 |
| In ASD | no |
| Allosteric Prediction | no (-0.083709262) |
| Ortholog in Animals | Alpaca_ NKX2-1 ( ortholog_one2one ) Dog_ NKX2-1 ( ortholog_one2one ) GuineaPig_ NKX2-1 ( ortholog_one2one ) Macaque_ NKX2-1 ( ortholog_one2one ) Mouse_ Nkx2-1 ( ortholog_one2one ) Pig_ NKX2-1 ( ortholog_one2one ) Rat_ Nkx2-1 ( ortholog_one2one ) |
| Ohnologs | NKX2-4 |
| Paralogs | NKX6-3, NKX2-8, NKX1-2, NKX2-3, NKX2-2, NKX6-1, NKX3-2, NKX1-1, NKX2-5, NKX6-2, NKX2-6, NKX2-4, NKX3-1 |
| Tissue | lung, thyroid, brain |
| Tissue Specificity | Thyroid and lung. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs137852692 rs28936672 rs28936671 rs537209983 |
| Subcellular location [CC] | Nucleus {ECO:0000250|UniProtKB:P50220}. |
| Mouse PG classification | NA |
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