| Gene Information | |
|---|---|
| Gene Name | NKG2D |
| Organism | Homo sapiens (Human) |
| Gene Length | 216 |
| Protein Names | NKG2-D type II integral membrane protein (Killer cell lectin-like receptor subfamily K member 1) (NK cell receptor D) (NKG2-D-activating NK receptor) (CD antigen CD314) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P26718 |
| Gene Card | KLRK1 |
| Uniprot ID | P26718 |
| Pfam | PF00059 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in natural killer (NK) cells, CD8(+) alpha-beta and gamma-delta T-cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC. Expressed in interferon-producing killer dendritic cells (IKDCs). {ECO:0000269|PubMed:10426993, ECO:0000269|PubMed:15294961, ECO:0000269|PubMed:16444266}. |
| Pharmacological Animal Models | 0.066005(Chimpanzee);0.140650(Mouse);NULL(Rat);0.020000(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1HYR (X-ray 2.70A ) 1KCG (X-ray 2.60A ) 1MPU (X-ray 2.50A ) 4PDC (X-ray 1.99A ) 4S0U (X-ray 2.35A ) |
| DBSNP | rs2255336 rs2306182 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:10426994, ECO:0000269|PubMed:11015446, ECO:0000269|PubMed:15294961}; Single-pass type II membrane protein {ECO:0000269|PubMed:10426994, ECO:0000269|PubMed:11015446, ECO:0000269|PubMed:15294961}. Note=Colocalized with HCST on the cell surface. |
| Mouse PG classification | NA |
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