| Gene Information | |
|---|---|
| Gene Name | NKG2C |
| Organism | Homo sapiens (Human) |
| Gene Length | 231 |
| Protein Names | NKG2-C type II integral membrane protein (CD159 antigen-like family member C) (NK cell receptor C) (NKG2-C-activating NK receptor) (CD antigen CD159c) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P26717 |
| Gene Card | KLRC2 |
| Uniprot ID | P26717 |
| Pfam | PF00059 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in NK cell subsets, in particular in adaptive CD57-positive NK cells (at protein level) (PubMed:20952657, PubMed:21825173). Expressed in terminally differentiated cytotoxic gamma-delta T cells (at protein level) (PubMed:20952657). Expressed in alpha-beta T cells subsets (at protein level) (PubMed:20952657). KLRD1-KLRC1 and KLRD1-KLRC2 are differentially expressed within NK and T cell populations, with only minor subsets expressing both receptor complexes (at protein level) (PubMed:20952657). {ECO:0000269|PubMed:20952657, ECO:0000269|PubMed:21825173}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2L35 (NMR - ) |
| DBSNP | rs28403159 rs1141715 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:20952657, ECO:0000269|PubMed:21825173}; Single-pass type II membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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