Gene Information
Gene NameNKG2A
OrganismHomo sapiens (Human)
Gene Length233
Protein NamesNKG2-A/NKG2-B type II integral membrane protein (CD159 antigen-like family member A) (NK cell receptor A) (NKG2-A/B-activating NK receptor) (CD antigen CD159a)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBP26715
Gene CardKLRC1
Uniprot IDP26715
PfamPF00059
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityPredominantly expressed in NK cells (at protein level) (PubMed:9430220, PubMed:9485206, PubMed:20952657). Expressed in intraepithelial CD8-positive T cell subsets with higher frequency in gamma-delta T cells than alpha-beta T cells (at protein level) (PubMed:18064301). Expressed in memory gamma-delta T cells (at protein level) (PubMed:20952657). Restricted to a subset of memory/effector CD8-positive alpha-beta T cells (at protein level) (PubMed:12387742). Expressed in intratumoral NK and CD8-positive T cells (PubMed:30503213). Expressed in melanoma-specific cytotoxic T cell clones (at protein level) (PubMed:9485206). KLRD1-KLRC1 and KLRD1-KLRC2 are differentially expressed in NK and T cell populations, with only minor subsets expressing both receptor complexes (at protein level) (PubMed:20952657). {ECO:0000269|PubMed:12387742, ECO:0000269|PubMed:18064301, ECO:0000269|PubMed:20952657, ECO:0000269|PubMed:30503213, ECO:0000269|PubMed:9430220, ECO:0000269|PubMed:9485206}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.028571(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2RMX  (NMR  -  )  2YU7  (NMR  -  )  3BDW  (X-ray  2.50A  )  3CDG  (X-ray  3.40A  )  3CII  (X-ray  4.41A  ) 
DBSNP rs2253849 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:12165520, ECO:0000269|PubMed:20952657};
Single-pass type II membrane protein {ECO:0000255}.
Mouse PG classificationNA
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