| Gene Information | |
|---|---|
| Gene Name | DHH |
| Organism | Homo sapiens (Human) |
| Gene Length | 396 |
| Protein Names | Desert hedgehog protein (DHH) (EC 3.1.-.-) (HHG-3) [Cleaved into: Desert hedgehog protein N-product (DHH-N)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000139549 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O43323 |
| Gene Card | DHH |
| Uniprot ID | O43323 |
| Pfam | PF01085; PF01079 |
| In ASD | no |
| Allosteric Prediction | no (-0.409294154) |
| Ortholog in Animals | Alpaca_ DHH ( ortholog_one2one ) Dog_ DHH ( ortholog_one2one ) GuineaPig_ DHH ( ortholog_one2one ) Macaque_ DHH ( ortholog_one2one ) Mouse_ Dhh ( ortholog_one2one ) Pig_ DHH ( ortholog_one2one ) Rat_ Dhh ( ortholog_one2one ) Rabbit_ DHH ( ortholog_one2one ) |
| Ohnologs | IHH, SHH |
| Paralogs | IHH, SHH |
| Tissue | testis, tibial.nerve |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2WFQ (X-ray 1.85A ) 2WFR (X-ray 1.95A ) 2WG3 (X-ray 2.60A ) 3N1G (X-ray 1.90A ) 3N1Q (X-ray 2.89A ) |
| DBSNP | rs111033589 |
| Subcellular location [CC] | [Desert hedgehog protein N-product]: Cell membrane {ECO:0000250|UniProtKB:Q62226}; Lipid-anchor {ECO:0000250|UniProtKB:Q62226}.; [Desert hedgehog protein]: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q15465}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q15465}. Secreted {ECO:0000269|PubMed:33063110}. Cell membrane {ECO:0000269|PubMed:24342078}. Note=Co-localizes with HHAT in the ER and Golgi membrane. {ECO:0000250|UniProtKB:Q15465}. |
| Mouse PG classification | HPG |
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