| Gene Information | |
|---|---|
| Gene Name | NIN |
| Organism | Homo sapiens (Human) |
| Gene Length | 2090 |
| Protein Names | Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000100503 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q8N4C6 |
| Gene Card | NIN |
| Uniprot ID | Q8N4C6 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.646279814) |
| Ortholog in Animals | Alpaca_ NIN ( ortholog_one2one ) Dog_ NIN ( ortholog_one2one ) GuineaPig_ NIN ( ortholog_one2one ) Macaque_ NIN ( ortholog_one2one ) Mouse_ Nin ( ortholog_one2one ) Pig_ NIN ( ortholog_one2one ) Rat_ Nin ( ortholog_one2one ) Rabbit_ NIN ( ortholog_one2one ) |
| Ohnologs | NINL |
| Paralogs | NINL |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Highly expressed in heart and skeletal muscle. Isoform 1 is more expressed than isoform 5. {ECO:0000269|PubMed:11004522, ECO:0000269|PubMed:11162463}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.05(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2236316 rs12882191 rs187464517 rs2073347 rs387907308 rs12717411 rs2295847 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:11004522, ECO:0000269|PubMed:11956314, ECO:0000269|PubMed:12403812, ECO:0000269|PubMed:12927815, ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:15190203}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:23386061}. Note=Component of the core centrosome. Arranged in a tubular conformation with an open and a closed end within the centrosome. In the mother centrosome, it localizes at both ends of the centrosome tube, including the site of centrosome duplication, while in the daughter centrosome it is present only at the closed end. Requires PCM1 for centrosome localization. Localizes to the subdistal appendage region of the centriole in a DCTN1-dependent manner. {ECO:0000269|PubMed:11956314, ECO:0000269|PubMed:12403812, ECO:0000269|PubMed:23386061}.; [Isoform 6]: Cytoplasm {ECO:0000250|UniProtKB:Q61043}. Note=Seems to have a dominant-negative effect on localization of other isoforms, promoting their dissociation from the centrosome. {ECO:0000250|UniProtKB:Q61043}. |
| Mouse PG classification | LPG |
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