| Gene Information | |
|---|---|
| Gene Name | NIK |
| Organism | Homo sapiens (Human) |
| Gene Length | 1239 |
| Protein Names | Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | O95819 |
| Gene Card | MAP4K4 |
| Uniprot ID | O95819 |
| Pfam | PF00780; PF00069 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Isoform 5 is abundant in the brain. Isoform 4 is predominant in the liver, skeletal muscle and placenta. {ECO:0000269|PubMed:9890973}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4OBO (X-ray 2.10A ) 4OBP (X-ray 2.27A ) 4OBQ (X-ray 2.19A ) 4RVT (X-ray 2.40A ) 4U3Y (X-ray 1.45A ) 4U3Z (X-ray 2.09A ) 4U40 (X-ray 2.30A ) 4U41 (X-ray 2.20A ) 4U42 (X-ray 2.50A ) 4U43 (X-ray 2.18A ) 4U44 (X-ray 2.43A ) 4U45 (X-ray 2.58A ) 4ZK5 (X-ray 2.89A ) 4ZP5 (X-ray 2.29A ) 5DI1 (X-ray 2.90A ) 5J95 (X-ray 2.50A ) 5W5Q (X-ray 2.33A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:14966141}. |
| Mouse PG classification | NA |
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