| Gene Information | |
|---|---|
| Gene Name | NHE1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 815 |
| Protein Names | Sodium/hydrogen exchanger 1 (APNH) (Na(+)/H(+) antiporter, amiloride-sensitive) (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P19634 |
| Gene Card | SLC9A1 |
| Uniprot ID | P19634 |
| Pfam | PF00999; PF16644 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Kidney and intestine. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001759(Rat);0.026667(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1Y4E (NMR - ) 2BEC (X-ray 2.70A ) 2E30 (NMR - ) 2HTG (NMR - ) 2KBV (NMR - ) 2L0E (NMR - ) 2MDF (NMR - ) 2YGG (X-ray 2.23A ) 6BJF (NMR - ) 6NUC (X-ray 1.90A ) 6NUF (X-ray 1.90A ) 6NUU (X-ray 2.30A ) 6ZBI (NMR - ) 7DSV (EM 3.40A ) 7DSW (EM 3.30A ) 7DSX (EM 3.50A ) |
| DBSNP | rs786204831 rs35703140 |
| Subcellular location [CC] | Membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane; Multi-pass membrane protein. Note=Colocalizes with CHP1 at the reticulum endoplasmic (By similarity). Colocalizes with CHP1 and CHP2 at the plasma membrane. {ECO:0000250}. |
| Mouse PG classification | NA |
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