| Gene Information | |
|---|---|
| Gene Name | NGFR |
| Organism | Homo sapiens (Human) |
| Gene Length | 427 |
| Protein Names | Tumor necrosis factor receptor superfamily member 16 (Gp80-LNGFR) (Low affinity neurotrophin receptor p75NTR) (Low-affinity nerve growth factor receptor) (NGF receptor) (p75 ICD) (CD antigen CD271) |
| Target Name | low-affinity nerve growth factor receptor |
| Target Type | Successful target |
| Gene Age | 645 ( ENSG00000064300 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P08138 |
| Gene Card | NGFR |
| Uniprot ID | P08138 |
| Pfam | PF00531; PF18422; PF00020 |
| In ASD | no |
| Allosteric Prediction | yes (0.626593171) |
| Ortholog in Animals | Alpaca_ NGFR ( ortholog_one2one ) Dog_ NGFR ( ortholog_one2one ) GuineaPig_ NGFR ( ortholog_one2one ) Macaque_ NGFR ( ortholog_one2one ) Mouse_ Ngfr ( ortholog_one2one ) Pig_ NGFR ( ortholog_one2one ) Rat_ Ngfr ( ortholog_one2one ) Rabbit_ NGFR ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TNFRSF25, TNFRSF6B, CD40, TNFRSF21, TNFRSF1A, TNFRSF10C, TNFRSF11B, TNFRSF10B, TNFRSF11A, CD27, FAS, TNFRSF10A, TNFRSF9, TNFRSF18, TNFRSF8, LTBR, RELT, TNFRSF10D, TNFRSF4, TNFRSF14, TNFRSF1B |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001680(Rat);0.211587(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2N80 (NMR - ) 2N83 (NMR - ) 2N97 (NMR - ) 3EWV (X-ray 2.60A ) 5ZGG (NMR - ) 7CSQ (NMR - ) |
| DBSNP | rs2072446 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:3022937}; Single-pass type I membrane protein {ECO:0000305}. Perikaryon {ECO:0000250|UniProtKB:Q9Z0W1}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q9Z0W1}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q9Z0W1}. |
| Mouse PG classification | NA |
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