| Gene Information | |
|---|---|
| Gene Name | NGF |
| Organism | Homo sapiens (Human) |
| Gene Length | 241 |
| Protein Names | Beta-nerve growth factor (Beta-NGF) |
| Target Name | beta-nerve growth factor |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000134259 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P01138 |
| Gene Card | NGF |
| Uniprot ID | P01138 |
| Pfam | PF00243 |
| In ASD | yes |
| Allosteric Prediction | yes (1.144261511) |
| Ortholog in Animals | Dog_ NGF ( ortholog_one2one ) GuineaPig_ NGF ( ortholog_one2one ) Macaque_ NGF ( ortholog_one2one ) Mouse_ Ngf ( ortholog_one2one ) Pig_ NGF ( ortholog_one2one ) Rat_ Ngf ( ortholog_one2one ) Rabbit_ NGF ( ortholog_one2one ) |
| Ohnologs | BDNF, NTF3 |
| Paralogs | NTF3, NTF4, BDNF |
| Tissue | left.ventricle, ovary, tricuspid.valve, uterus |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.1(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1SG1 (X-ray 2.40A ) 1WWW (X-ray 2.20A ) 2IFG (X-ray 3.40A ) 4EDW (X-ray 2.48A ) 4EDX (X-ray 2.50A ) 4ZBN (X-ray 2.45A ) 5JZ7 (X-ray 3.40A ) 6YW8 (NMR - ) |
| DBSNP | rs6330 rs11466110 rs11466111 rs11466112 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:20978020}. Endosome lumen {ECO:0000250|UniProtKB:P01139}. Note=ProNGF is endocytosed after binding to the cell surface receptor formed by SORT1 and NGFR. {ECO:0000250|UniProtKB:P01139}. |
| Mouse PG classification | LPG |
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