| Gene Information | |
|---|---|
| Gene Name | NGEF |
| Organism | Homo sapiens (Human) |
| Gene Length | 710 |
| Protein Names | Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000066248 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q8N5V2 |
| Gene Card | NGEF |
| Uniprot ID | Q8N5V2 |
| Pfam | PF00169; PF00621; PF00018 |
| In ASD | no |
| Allosteric Prediction | yes (0.047351619) |
| Ortholog in Animals | Alpaca_ NGEF ( ortholog_one2one ) Dog_ NGEF ( ortholog_one2one ) GuineaPig_ NGEF ( ortholog_one2one ) Macaque_ NGEF ( ortholog_one2one ) Mouse_ Ngef ( ortholog_one2one ) Pig_ NGEF ( ortholog_one2one ) Rat_ Ngef ( ortholog_one2one ) |
| Ohnologs | ARHGEF5, ARHGEF26, ARHGEF15, ARHGEF34P, ARHGEF16, ARHGEF19 |
| Paralogs | ARHGEF15, ARHGEF19, ARHGEF5, ARHGEF35, ARHGEF16, ARHGEF26 |
| Tissue | adrenal.gland |
| Tissue Specificity | Highly expressed in brain specifically in caudate nucleus and to a lower extent in amygdala and hippocampus. Also detected in lung. {ECO:0000269|PubMed:10777665}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2271703 rs4973588 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Note=Associated with membranes. Localizes to axonal growth cones (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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