| Gene Information | |
|---|---|
| Gene Name | NEK8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 692 |
| Protein Names | Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (Nima-related protein kinase 12a) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000160602 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q86SG6 |
| Gene Card | NEK8 |
| Uniprot ID | Q86SG6 |
| Pfam | PF00069; PF00415 |
| In ASD | no |
| Allosteric Prediction | no (-1.000038758) |
| Ortholog in Animals | Alpaca_ NEK8 ( ortholog_one2one ) Dog_ NEK8 ( ortholog_one2one ) GuineaPig_ NEK8 ( ortholog_one2one ) Macaque_ NEK8 ( ortholog_one2one ) Mouse_ Nek8 ( ortholog_one2one ) Pig_ NEK8 ( ortholog_one2one ) Rat_ Nek8 ( ortholog_one2one ) Rabbit_ NEK8 ( ortholog_one2one ) |
| Ohnologs | NEK9 |
| Paralogs | NEK5, NEK11, NEK2, NEK7, NEK9, NEK3, NEK6, NEK10 |
| Tissue | NA |
| Tissue Specificity | Highest expression in thyroid, adrenal gland and skin. Low levels in spleen, colon and uterus. Overexpressed in breast tumors, with highest expression in infiltrating ductal carcinomas and moderate levels in mucinous adenocarcinoma. {ECO:0000269|PubMed:15019993}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs199962228 rs118204032 rs146326420 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:18199800}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q91ZR4}. Cell projection, cilium {ECO:0000269|PubMed:18199800}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:18199800}. Note=Predominantly cytoplasmic. Localizes to the proximal region of the primary cilium and is not observed in dividing cells. {ECO:0000250|UniProtKB:Q91ZR4}. |
| Mouse PG classification | HPG |
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