| Gene Information | |
|---|---|
| Gene Name | NGAL |
| Organism | Homo sapiens (Human) |
| Gene Length | 198 |
| Protein Names | Neutrophil gelatinase-associated lipocalin (NGAL) (25 kDa alpha-2-microglobulin-related subunit of MMP-9) (Lipocalin-2) (Oncogene 24p3) (Siderocalin) (p25) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P80188 |
| Gene Card | LCN2 |
| Uniprot ID | P80188 |
| Pfam | PF00061 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Detected in neutrophils (at protein level) (PubMed:7683678, PubMed:8298140). Expressed in bone marrow and in tissues that are prone to exposure to microorganism. High expression is found in bone marrow as well as in uterus, prostate, salivary gland, stomach, appendix, colon, trachea and lung. Not found in the small intestine or peripheral blood leukocytes. {ECO:0000269|PubMed:7683678, ECO:0000269|PubMed:8298140, ECO:0000269|PubMed:9339356}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1DFV (X-ray 2.60A ) 1L6M (X-ray 2.40A ) 1NGL (NMR - ) 1QQS (X-ray 2.40A ) 1X71 (X-ray 2.10A ) 1X89 (X-ray 2.10A ) 1X8U (X-ray 2.20A ) 3BY0 (X-ray 2.57A ) 3CBC (X-ray 2.17A ) 3CMP (X-ray 2.80A ) 3DSZ (X-ray 2.00A ) 3DTQ (X-ray 2.50A ) 3FW4 (X-ray 2.30A ) 3FW5 (X-ray 2.30A ) 3HWD (X-ray 2.95A ) 3HWE (X-ray 2.80A ) 3HWF (X-ray 3.20A ) 3HWG (X-ray 2.19A ) 3I0A (X-ray 2.60A ) 3K3L (X-ray 2.62A ) 3PEC (X-ray 2.19A ) 3PED (X-ray 2.30A ) 3T1D (X-ray 2.30A ) 3TF6 (X-ray 2.35A ) 3TZS (X-ray 2.45A ) 3U0D (X-ray 2.51A ) 4GH7 (X-ray 2.60A ) 4IAW (X-ray 2.40A ) 4IAX (X-ray 1.90A ) 4K19 (X-ray 2.74A ) 4MVI (X-ray 1.70A ) 4MVK (X-ray 1.50A ) 4MVL (X-ray 2.30A ) 4QAE (X-ray 2.10A ) 4ZFX (X-ray 2.55A ) 4ZHC (X-ray 2.04A ) 4ZHD (X-ray 2.05A ) 4ZHF (X-ray 2.45A ) 4ZHG (X-ray 2.05A ) 4ZHH (X-ray 2.04A ) 5JR8 (X-ray 2.65A ) 5KHP (X-ray 2.65A ) 5KIC (X-ray 2.70A ) 5KID (X-ray 2.15A ) 5MHH (X-ray 2.00A ) 5N47 (X-ray 3.00A ) 5N48 (X-ray 1.60A ) 5NKN (X-ray 2.20A ) 6GQZ (X-ray 1.40A ) 6GR0 (X-ray 2.50A ) 6O5D (X-ray 2.40A ) 6QMU (X-ray 1.98A ) 6S8V (X-ray 1.80A ) 6SUA (X-ray 2.75A ) 6Z2C (X-ray 1.80A ) 6Z6Z (X-ray 1.78A ) |
| DBSNP | NA |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:12453413, ECO:0000269|PubMed:27780864, ECO:0000269|PubMed:7683678}. Cytoplasmic granule lumen {ECO:0000269|PubMed:8298140}. Cytoplasmic vesicle lumen {ECO:0000269|PubMed:12453413}. Note=Upon binding to the SLC22A17 (24p3R) receptor, it is internalized (By similarity). Releases the bound iron in the acidic lumen of cytoplasmic vesicles (PubMed:12453413, PubMed:20581821). {ECO:0000250|UniProtKB:P11672, ECO:0000269|PubMed:12453413, ECO:0000269|PubMed:20581821}. |
| Mouse PG classification | NA |
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