| Gene Information | |
|---|---|
| Gene Name | NFS1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 457 |
| Protein Names | Cysteine desulfurase (EC 2.8.1.7) |
| Target Name | cysteine desulfurase, mitochondrial |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000244005 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q9Y697 |
| Gene Card | NFS1 |
| Uniprot ID | Q9Y697 |
| Pfam | PF00266 |
| In ASD | no |
| Allosteric Prediction | no (-0.455254315) |
| Ortholog in Animals | Alpaca_ NFS1 ( ortholog_one2one ) Alpaca_ NFS1 ( ortholog_one2many ) Dog_ NFS1 ( ortholog_one2one ) GuineaPig_ NFS1 ( ortholog_one2one ) Macaque_ NFS1 ( ortholog_one2one ) Mouse_ Nfs1 ( ortholog_one2one ) Pig_ NFS1 ( ortholog_one2one ) Rat_ Nfs1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SCLY |
| Tissue | NA |
| Tissue Specificity | Predominantly expressed in heart and skeletal muscle. Also found in brain, liver and pancreas. {ECO:0000269|PubMed:9885568}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);0.003490(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5KZ5 (EM 14.30A ) 5USR (X-ray 3.09A ) 5WGB (X-ray 2.75A ) 5WKP (X-ray 3.15A ) 5WLW (X-ray 3.32A ) 6NZU (EM 3.20A ) 6UXE (X-ray 1.57A ) 6W1D (X-ray 1.79A ) 6WI2 (X-ray 1.95A ) 6WIH (X-ray 1.90A ) 7RTK (X-ray 2.50A ) |
| DBSNP | NA |
| Subcellular location [CC] | [Isoform Mitochondrial]: Mitochondrion {ECO:0000269|PubMed:19454487, ECO:0000269|PubMed:26702583, ECO:0000269|PubMed:9885568}.; [Isoform Cytoplasmic]: Cytoplasm {ECO:0000269|PubMed:9885568}. Nucleus {ECO:0000269|PubMed:19454487, ECO:0000269|PubMed:9885568}. |
| Mouse PG classification | NA |
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