Gene Information
Gene NameNFKB1
OrganismHomo sapiens (Human)
Gene Length968
Protein NamesNuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit]
Target Namedna-binding factor kbf1
Target TypeClinical trial target
Gene Age544 ( ENSG00000109320 )
Evolutionary StageOpisthokonta
AlphaFoldDBP19838
Gene CardNFKB1
Uniprot IDP19838
PfamPF00023; PF12796; PF00531; PF16179; PF00554
In ASDno
Allosteric Predictionyes (1.389110039)
Ortholog in AnimalsAlpaca_ NFKB1 ( ortholog_one2one )
Dog_ NFKB1 ( ortholog_one2one )
GuineaPig_ NFKB1 ( ortholog_one2one )
Macaque_ NFKB1 ( ortholog_one2one )
Mouse_ Nfkb1 ( ortholog_one2one )
Pig_ NFKB1 ( ortholog_one2one )
Rat_ Nfkb1 ( ortholog_one2one )
Rabbit_ NFKB1 ( ortholog_one2one )
OhnologsNFKB2, NFKBIE
ParalogsREL, RELA, RELB, NFKB2
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.030769(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1MDI  (NMR  -  )  1MDJ  (NMR  -  )  1MDK  (NMR  -  )  1NFI  (X-ray  2.70A  )  1SVC  (X-ray  2.60A  )  2DBF  (NMR  -  )  2O61  (X-ray  2.80A  )  3GUT  (X-ray  3.59A  )  7LEQ  (X-ray  2.24A  )  7LET  (X-ray  2.40A  )  7LF4  (X-ray  2.85A  )  7LFC  (X-ray  2.10A  )  7RG4  (X-ray  2.60A  )  7RG5  (X-ray  2.15A  ) 
DBSNP rs4648065  rs4648072  rs4648085  rs4648086  rs4648099  rs4648118 
Subcellular location [CC]Nucleus. Cytoplasm. Note=Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B).
Mouse PG classificationNA
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