| Gene Information | |
|---|---|
| Gene Name | LCP2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 533 |
| Protein Names | Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000043462 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q13094 |
| Gene Card | LCP2 |
| Uniprot ID | Q13094 |
| Pfam | PF07647; PF00017 |
| In ASD | no |
| Allosteric Prediction | yes (0.093709584) |
| Ortholog in Animals | Alpaca_ LCP2 ( ortholog_one2one ) Dog_ LCP2 ( ortholog_one2one ) GuineaPig_ LCP2 ( ortholog_one2one ) Macaque_ LCP2 ( ortholog_one2one ) Mouse_ Lcp2 ( ortholog_one2one ) Pig_ LCP2 ( ortholog_one2one ) Rat_ Lcp2 ( ortholog_one2one ) Rabbit_ LCP2 ( ortholog_one2one ) |
| Ohnologs | BLNK, CLNK |
| Paralogs | CLNK, BLNK, SH2D6 |
| Tissue | spleen, whole.blood |
| Tissue Specificity | Highly expressed in spleen, thymus and peripheral blood leukocytes. Highly expressed also in T-cell and monocytic cell lines, expressed at lower level in B-cell lines. Not detected in fibroblast or neuroblastoma cell lines. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002240(Rat);0.063636(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1H3H (NMR - ) 1YWO (X-ray 1.81A ) 2EAP (NMR - ) 2ROR (NMR - ) 6ZCJ (X-ray 1.53A ) |
| DBSNP | rs34192428 |
| Subcellular location [CC] | Cytoplasm {ECO:0000305}. |
| Mouse PG classification | NA |
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