| Gene Information | |
|---|---|
| Gene Name | NFE2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 373 |
| Protein Names | Transcription factor NF-E2 45 kDa subunit (Leucine zipper protein NF-E2) (Nuclear factor, erythroid-derived 2 45 kDa subunit) (p45 NF-E2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000123405 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q16621 |
| Gene Card | NFE2 |
| Uniprot ID | Q16621 |
| Pfam | PF03131 |
| In ASD | no |
| Allosteric Prediction | no (-0.445605608) |
| Ortholog in Animals | Alpaca_ NFE2 ( ortholog_one2one ) Dog_ NFE2 ( ortholog_one2one ) GuineaPig_ NFE2 ( ortholog_one2one ) Macaque_ NFE2 ( ortholog_one2one ) Mouse_ Nfe2 ( ortholog_one2one ) Pig_ NFE2 ( ortholog_one2one ) Rat_ Nfe2 ( ortholog_one2one ) Rabbit_ NFE2 ( ortholog_one2one ) |
| Ohnologs | NFE2L2 |
| Paralogs | NFE2L2, NFE2L3, NFE2L1 |
| Tissue | bone.marrow, spleen, whole.blood |
| Tissue Specificity | Expressed in hematopoietic cells and also in colon and testis. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2KZ5 (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus, PML body. Cytoplasm. Note=The sumoylated form locates to the nuclear bodies PML oncogenic domains (PODs). Translocated to the cytoplasm through interaction with ITCH. |
| Mouse PG classification | NA |
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