| Gene Information | |
|---|---|
| Gene Name | LATS2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1088 |
| Protein Names | Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase) |
| Target Name | large tumor suppressor homolog 2 |
| Target Type | Literature-reported target |
| Gene Age | 987 ( ENSG00000150457 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9NRM7 |
| Gene Card | LATS2 |
| Uniprot ID | Q9NRM7 |
| Pfam | PF00069; PF00433 |
| In ASD | no |
| Allosteric Prediction | no (-0.456802036) |
| Ortholog in Animals | Alpaca_ LATS2 ( ortholog_one2one ) Dog_ LATS2 ( ortholog_one2one ) GuineaPig_ LATS2 ( ortholog_one2one ) Macaque_ LATS2 ( ortholog_one2one ) Mouse_ Lats2 ( ortholog_one2one ) Pig_ LATS2 ( ortholog_one2one ) Rat_ Lats2 ( ortholog_one2one ) Rabbit_ LATS2 ( ortholog_one2one ) |
| Ohnologs | LATS1 |
| Paralogs | STK32B, MAST3, STK32A, MAST2, SGK1, MAST4, SGK2, SGK3, LATS1, STK32C, MAST1, DMPK, MASTL |
| Tissue | NA |
| Tissue Specificity | Expressed at high levels in heart and skeletal muscle and at lower levels in all other tissues examined. {ECO:0000269|PubMed:10673337, ECO:0000269|PubMed:10871863}. |
| Pharmacological Animal Models | 0.091789(Chimpanzee);0.031362(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4ZRI (X-ray 2.70A ) |
| DBSNP | rs55842804 rs558614 rs2770928 rs35368391 rs45523141 rs56116059 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Nucleus. Note=Colocalizes with AURKA at the centrosomes during interphase, early prophase and cytokinesis. Migrates to the spindle poles during mitosis, and to the midbody during cytokinesis. Translocates to the nucleus upon mitotic stress by nocodazole treatment. |
| Mouse PG classification | NA |
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