| Gene Information | |
|---|---|
| Gene Name | NEU4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 484 |
| Protein Names | Sialidase-4 (EC 3.2.1.18) (N-acetyl-alpha-neuraminidase 4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000204099 ) 3 ( ENSG00000277926 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q8WWR8 |
| Gene Card | NEU4 |
| Uniprot ID | Q8WWR8 |
| Pfam | PF13088 |
| In ASD | no |
| Allosteric Prediction | no (-1.132931397) |
| Ortholog in Animals | Alpaca_ NEU4 ( ortholog_one2one ) Dog_ NEU4 ( ortholog_one2one ) GuineaPig_ NEU4 ( ortholog_one2one ) Macaque_ NEU4 ( ortholog_one2one ) Mouse_ Neu4 ( ortholog_one2one ) Pig_ NEU4 ( ortholog_one2one ) Rat_ Neu4 ( ortholog_one2one ) |
| Ohnologs | NEU3 |
| Paralogs | NEU2, NEU3, NEU1 |
| Tissue | colon, liver |
| Tissue Specificity | [Isoform 1]: Predominant form in liver. Also expressed in brain, kidney and colon. {ECO:0000269|PubMed:14962670, ECO:0000269|PubMed:15847605}.; [Isoform 2]: Highly expressed in brain and at lower levels in kidney and liver. {ECO:0000269|PubMed:15847605}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs11545301 |
| Subcellular location [CC] | [Isoform 1]: Cell membrane {ECO:0000269|PubMed:21521691}; Peripheral membrane protein. Endoplasmic reticulum membrane {ECO:0000269|PubMed:15847605}; Peripheral membrane protein. Microsome membrane {ECO:0000269|PubMed:15847605}; Peripheral membrane protein. Mitochondrion membrane {ECO:0000269|PubMed:15847605, ECO:0000269|PubMed:19797320}; Peripheral membrane protein. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q8BZL1}. Note=Predominantly associates with endoplasmic reticulum membranes. Only a small fraction associates with mitochondrial and plasma membranes. {ECO:0000269|PubMed:19797320, ECO:0000269|PubMed:21521691}.; [Isoform 2]: Mitochondrion inner membrane {ECO:0000269|PubMed:15847605}; Peripheral membrane protein. Mitochondrion outer membrane {ECO:0000269|PubMed:15847605, ECO:0000269|PubMed:19797320}; Peripheral membrane protein. Lysosome lumen {ECO:0000269|PubMed:15213228}. Note=According to PubMed:15213228, isoform 2 is soluble, N-glycosylated and found in the lumen of lysosomes. However, no signal sequence nor N-glycosylation site is predicted from the sequence. |
| Mouse PG classification | NA |
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