| Gene Information | |
|---|---|
| Gene Name | NEU2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 380 |
| Protein Names | Sialidase-2 (EC 3.2.1.18) (Cytosolic sialidase) (N-acetyl-alpha-neuraminidase 2) |
| Target Name | sialidase-2 |
| Target Type | NA |
| Gene Age | 424 ( ENSG00000115488 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9Y3R4 |
| Gene Card | NEU2 |
| Uniprot ID | Q9Y3R4 |
| Pfam | PF13088 |
| In ASD | no |
| Allosteric Prediction | no (-0.491550401) |
| Ortholog in Animals | Alpaca_ NEU2 ( ortholog_one2one ) Dog_ NEU2 ( ortholog_one2one ) GuineaPig_ NEU2 ( ortholog_one2one ) Macaque_ NEU2 ( ortholog_one2one ) Mouse_ Neu2 ( ortholog_one2one ) Pig_ NEU2 ( ortholog_one2one ) Rat_ Neu2 ( ortholog_one2one ) Rabbit_ NEU2 ( ortholog_one2one ) |
| Ohnologs | NEU3 |
| Paralogs | NEU4, NEU3, NEU1 |
| Tissue | NA |
| Tissue Specificity | Expressed in skeletal muscle, fetal liver and embryonic carcinoma cell line NT2-D1. {ECO:0000269|PubMed:10191093}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1SNT (X-ray 1.75A ) 1SO7 (X-ray 1.49A ) 1VCU (X-ray 2.85A ) 2F0Z (X-ray 2.80A ) 2F10 (X-ray 2.90A ) 2F11 (X-ray 2.57A ) 2F12 (X-ray 2.27A ) 2F13 (X-ray 2.26A ) 2F24 (X-ray 1.76A ) 2F25 (X-ray 1.95A ) 2F26 (X-ray 1.58A ) 2F27 (X-ray 2.15A ) 2F28 (X-ray 1.67A ) 2F29 (X-ray 2.92A ) 4NC5 (X-ray 2.51A ) 4NCS (X-ray 2.20A ) |
| DBSNP | rs2233384 rs2233385 rs2233390 rs2233391 rs2233393 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:10561456}. |
| Mouse PG classification | NA |
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