| Gene Information | |
|---|---|
| Gene Name | NESCA |
| Organism | Homo sapiens (Human) |
| Gene Length | 902 |
| Protein Names | AP-4 complex accessory subunit RUSC1 (New molecule containing SH3 at the carboxy-terminus) (Nesca) (RUN and SH3 domain-containing protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9BVN2 |
| Gene Card | RUSC1 |
| Uniprot ID | Q9BVN2 |
| Pfam | PF02759; PF14604 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Predominantly expressed in brain. {ECO:0000269|PubMed:15024033}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4GIW (X-ray 2.00A ) |
| DBSNP | rs12061020 rs35826120 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:15024033}. Nucleus {ECO:0000269|PubMed:15024033}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8BG26}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q8BG26}. Early endosome {ECO:0000250|UniProtKB:Q8BG26}. Postsynaptic density {ECO:0000250|UniProtKB:Q8BG26}. Golgi apparatus {ECO:0000250|UniProtKB:Q8BG26}. Note=Translocated to the nuclear envelope upon stimulation with NGF (PubMed:15024033). Associated with membranes and microtubules (By similarity). {ECO:0000250|UniProtKB:Q8BG26, ECO:0000269|PubMed:15024033}. |
| Mouse PG classification | NA |
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