| Gene Information | |
|---|---|
| Gene Name | NEMO |
| Organism | Homo sapiens (Human) |
| Gene Length | 419 |
| Protein Names | NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9Y6K9 |
| Gene Card | IKBKG |
| Uniprot ID | Q9Y6K9 |
| Pfam | PF16516; PF11577 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2JVX (NMR - ) 2JVY (NMR - ) 3BRT (X-ray 2.25A ) 3BRV (X-ray 2.20A ) 3CL3 (X-ray 3.20A ) 3FX0 (X-ray 3.20A ) 4BWN (X-ray 2.27A ) 5AAY (NMR - ) 5LDE (X-ray 3.38A ) 6MI3 (X-ray 1.78A ) 6MI4 (X-ray 2.50A ) 6XX0 (X-ray 2.60A ) 6YEK (X-ray 3.20A ) 7TV4 (X-ray 4.20A ) |
| DBSNP | rs148695964 rs179363896 rs179363895 rs137853328 rs179363866 rs1057520292 rs179363868 rs1198984417 rs179363869 rs137853330 rs179363867 rs137853331 rs137853332 rs179363865 rs137853327 rs137853322 rs137853326 rs137853325 rs137853326 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:14651848}. Nucleus {ECO:0000269|PubMed:14651848}. Note=Sumoylated NEMO accumulates in the nucleus in response to genotoxic stress. {ECO:0000269|PubMed:14651848}. |
| Mouse PG classification | NA |
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